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000280056 1001_ $$aEhrhardt, Nina M$$b0
000280056 245__ $$aMemory dependent modulation of hippocampal theta power through frontoparietal phase synchronous brain stimulation.
000280056 260__ $$a[London]$$bSpringer Nature$$c2025
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000280056 520__ $$aTargeting subcortical regions like the hippocampus with non-invasive brain stimulation is challenging due to predominantly cortical distribution of electric fields. Frontoparietal phase-synchronous transcranial alternating stimulation (tACS) offers a promising approach to modulate hippocampal functions, though its ability to induce modulation of oscillatory activity in deep subcortical targets remains to be shown. In this pilot study, we applied dual-site theta-tACS (in-phase between left frontoparietal regions) during a temporal order memory task. To quantify hippocampal activity and connectivity, we performed subcortical source analyses of electroencephalography (EEG) data using a hierarchical subspace pursuit algorithm. While memory did not differ between tACS and sham conditions, we observed tACS-induced increases in hippocampal theta power and its connectivity in individuals with superior memory performance. This study provides first-time evidence that phase-synchronized tACS over lateral frontoparietal areas influences hippocampal theta oscillatory activity, substantiating its potential to modulate hippocampal functions in health and disease.
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000280056 650_2 $$2MeSH$$aHippocampus: physiology
000280056 650_2 $$2MeSH$$aHumans
000280056 650_2 $$2MeSH$$aMale
000280056 650_2 $$2MeSH$$aTheta Rhythm: physiology
000280056 650_2 $$2MeSH$$aFemale
000280056 650_2 $$2MeSH$$aAdult
000280056 650_2 $$2MeSH$$aParietal Lobe: physiology
000280056 650_2 $$2MeSH$$aFrontal Lobe: physiology
000280056 650_2 $$2MeSH$$aMemory: physiology
000280056 650_2 $$2MeSH$$aElectroencephalography
000280056 650_2 $$2MeSH$$aTranscranial Direct Current Stimulation: methods
000280056 650_2 $$2MeSH$$aYoung Adult
000280056 650_2 $$2MeSH$$aPilot Projects
000280056 7001_ $$aHanna, Jevri$$b1
000280056 7001_ $$0P:(DE-2719)9001373$$aHayek, Dayana$$b2$$udzne
000280056 7001_ $$aFleischmann, Robert$$b3
000280056 7001_ $$aGrittner, Ulrike$$b4
000280056 7001_ $$aThielscher, Axel$$b5
000280056 7001_ $$0P:(DE-2719)2812683$$aFlöel, Agnes$$b6$$udzne
000280056 7001_ $$aAntonenko, Daria$$b7
000280056 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-025-09841-y$$gVol. 15, no. 1, p. 26504$$n1$$p26504$$tScientific reports$$v15$$x2045-2322$$y2025
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