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@ARTICLE{Ehrhardt:280056,
      author       = {Ehrhardt, Nina M and Hanna, Jevri and Hayek, Dayana and
                      Fleischmann, Robert and Grittner, Ulrike and Thielscher,
                      Axel and Flöel, Agnes and Antonenko, Daria},
      title        = {{M}emory dependent modulation of hippocampal theta power
                      through frontoparietal phase synchronous brain stimulation.},
      journal      = {Scientific reports},
      volume       = {15},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00893},
      pages        = {26504},
      year         = {2025},
      abstract     = {Targeting subcortical regions like the hippocampus with
                      non-invasive brain stimulation is challenging due to
                      predominantly cortical distribution of electric fields.
                      Frontoparietal phase-synchronous transcranial alternating
                      stimulation (tACS) offers a promising approach to modulate
                      hippocampal functions, though its ability to induce
                      modulation of oscillatory activity in deep subcortical
                      targets remains to be shown. In this pilot study, we applied
                      dual-site theta-tACS (in-phase between left frontoparietal
                      regions) during a temporal order memory task. To quantify
                      hippocampal activity and connectivity, we performed
                      subcortical source analyses of electroencephalography (EEG)
                      data using a hierarchical subspace pursuit algorithm. While
                      memory did not differ between tACS and sham conditions, we
                      observed tACS-induced increases in hippocampal theta power
                      and its connectivity in individuals with superior memory
                      performance. This study provides first-time evidence that
                      phase-synchronized tACS over lateral frontoparietal areas
                      influences hippocampal theta oscillatory activity,
                      substantiating its potential to modulate hippocampal
                      functions in health and disease.},
      keywords     = {Hippocampus: physiology / Humans / Male / Theta Rhythm:
                      physiology / Female / Adult / Parietal Lobe: physiology /
                      Frontal Lobe: physiology / Memory: physiology /
                      Electroencephalography / Transcranial Direct Current
                      Stimulation: methods / Young Adult / Pilot Projects},
      cin          = {AG Flöel},
      ddc          = {600},
      cid          = {I:(DE-2719)5000081},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40695870},
      doi          = {10.1038/s41598-025-09841-y},
      url          = {https://pub.dzne.de/record/280056},
}