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024 7 _ |a 10.1038/s41598-025-09841-y
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037 _ _ |a DZNE-2025-00893
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082 _ _ |a 600
100 1 _ |a Ehrhardt, Nina M
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245 _ _ |a Memory dependent modulation of hippocampal theta power through frontoparietal phase synchronous brain stimulation.
260 _ _ |a [London]
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|b Springer Nature
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520 _ _ |a Targeting subcortical regions like the hippocampus with non-invasive brain stimulation is challenging due to predominantly cortical distribution of electric fields. Frontoparietal phase-synchronous transcranial alternating stimulation (tACS) offers a promising approach to modulate hippocampal functions, though its ability to induce modulation of oscillatory activity in deep subcortical targets remains to be shown. In this pilot study, we applied dual-site theta-tACS (in-phase between left frontoparietal regions) during a temporal order memory task. To quantify hippocampal activity and connectivity, we performed subcortical source analyses of electroencephalography (EEG) data using a hierarchical subspace pursuit algorithm. While memory did not differ between tACS and sham conditions, we observed tACS-induced increases in hippocampal theta power and its connectivity in individuals with superior memory performance. This study provides first-time evidence that phase-synchronized tACS over lateral frontoparietal areas influences hippocampal theta oscillatory activity, substantiating its potential to modulate hippocampal functions in health and disease.
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650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Theta Rhythm: physiology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Parietal Lobe: physiology
|2 MeSH
650 _ 2 |a Frontal Lobe: physiology
|2 MeSH
650 _ 2 |a Memory: physiology
|2 MeSH
650 _ 2 |a Electroencephalography
|2 MeSH
650 _ 2 |a Transcranial Direct Current Stimulation: methods
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a Pilot Projects
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700 1 _ |a Hanna, Jevri
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700 1 _ |a Hayek, Dayana
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700 1 _ |a Fleischmann, Robert
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700 1 _ |a Grittner, Ulrike
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700 1 _ |a Thielscher, Axel
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700 1 _ |a Flöel, Agnes
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700 1 _ |a Antonenko, Daria
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773 _ _ |a 10.1038/s41598-025-09841-y
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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