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@ARTICLE{Masebo:280058,
      author       = {Masebo, Lehané and Whitfield, Tim and Demnitz-King,
                      Harriet and Heslegrave, Amanda and Poisnel, Géraldine and
                      Lutz, Antoine and Frison, Eric and Wirth, Miranka and Hye,
                      Abdul and Jessen, Frank and Ashton, Nicholas J. and
                      Zetterberg, Henrik and Marchant, Natalie L.},
      title        = {{C}an non-pharmacological interventions change levels of
                      neurofilament light in older adults at risk of dementia? {A}
                      secondary analysis of the {SCD}-{W}ell randomized clinical
                      trial},
      journal      = {The journal of prevention of Alzheimer's disease},
      volume       = {12},
      number       = {8},
      issn         = {2274-5807},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {DZNE-2025-00895},
      pages        = {100299},
      year         = {2025},
      abstract     = {Older adults with subjective cognitive decline (SCD) and/or
                      elevated neurofilament light (NfL), a neurodegeneration
                      biomarker, are at increased risk of dementia.
                      Non-pharmacological interventions offer a promising strategy
                      for reducing dementia risk, yet none have utilized NfL as a
                      marker of response in dementia prevention trials.To
                      investigate the effects of two non-pharmacological
                      interventions on NfL in older adults with SCD.SCD-Well was
                      an 8-week observer-blinded, randomized, clinical trial with
                      6-month follow-up, and was a part of the Horizon 2020
                      European Union-funded 'Medit-Ageing' project. Data were
                      analyzed from June 2022 to August 2024.Memory clinics at
                      four sites in France, Germany, Spain, and UK.Participants
                      were enrolled from March 2017 to January 2018 after
                      fulfilling SCD research criteria and performing within the
                      normal range on cognitive testing. Of the 147 participants
                      enrolled, 140 were included in this secondary analysis (7
                      did not consent to venipuncture).Participants were randomly
                      allocated to the Caring Mindfulness-Based Approach for
                      Seniors (CMBAS) intervention or a structurally matched
                      Health Self-Management Program (HSMP).Plasma NfL was
                      measured at baseline (V1), post-intervention (V2), and
                      6-month follow-up (V3), using Single molecule array
                      technology, and log-transformed for analyses.137 older
                      adults with SCD provided NfL data (mean [SD] age: 72.7 [6.8]
                      years; 62.0 $\%$ female; CMBAS, n = 70; HSMP, n = 67). NfL
                      data were available at V1 (n = 136), V2 (n = 119) and V3 (n
                      = 115). The visit-by-arm interaction was not statistically
                      significant, and no significant changes in NfL were observed
                      within the CMBAS or HSMP arms from V1 to V2. However, within
                      the HSMP arm, NfL levels reduced from V1 to V3 (-0.10, 95
                      $\%$ confidence interval [-0.18 to -0.02]). Modified
                      intention-to-treat analyses, which included 140
                      participants, supported these findings, and additionally
                      recorded significant reductions in the HSMP arm from V1 to
                      V2 (n = 140, -0.07 [-0.14 to -0.00]).In this study, NfL
                      levels were reduced at 6-month follow-up after a health
                      self-management program. Future interventions with longer
                      duration, extended follow-up and clinical endpoints will
                      help clarify whether NfL reductions are sustained over
                      extended timeframes and translate to lower dementia
                      incidence.ClinicalTrials.gov Identifier: (NCT03005652).},
      keywords     = {Behavior change (Other) / Blood (Other) / Blood-based
                      biomarkers (Other) / Fluid biomarkers (Other) /
                      Psychological intervention (Other)},
      cin          = {AG Wirth / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011 / I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40683836},
      doi          = {10.1016/j.tjpad.2025.100299},
      url          = {https://pub.dzne.de/record/280058},
}