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@ARTICLE{Etteldorf:280114,
      author       = {Etteldorf, Rika and Coors, Annabell and Estrada, Santiago
                      and Breteler, Monique M B and Ettinger, Ulrich},
      title        = {{R}egional {B}rain {V}olume and {C}ortical {T}hickness
                      {M}ediate {A}ge-{R}elated {D}ifferences in {E}ye {M}ovement
                      {C}ontrol.},
      journal      = {The journals of gerontology / Series B},
      volume       = {80},
      number       = {7},
      issn         = {1079-5014},
      address      = {Oxford [u.a.]},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2025-00897},
      pages        = {gbaf098},
      year         = {2025},
      abstract     = {Eye movements (EMs) are considered biomarkers for
                      age-related neurological or psychological deficits, and
                      oculomotor control has been shown to strongly decline with
                      age. This study aimed to understand the neural pathways of
                      these age-related changes.The analysis was based on 5,400
                      participants (aged 30-95 years) from the population-based
                      Rhineland Study. EMs were recorded using video-based
                      infrared oculography at 1,000 Hz. Brain structure measures
                      were obtained from T1-weighted MR images using FreeSurfer.
                      Relations of brain structure with EM outcomes were
                      quantified using multivariable linear regression models
                      while adjusting for age, sex, educational level, and
                      best-corrected visual acuity. Brain structure measures were
                      further analyzed as potential mediators in the relation
                      between age and EM outcomes.Larger volumes of the globus
                      pallidus and thalamus were associated with shorter saccadic
                      latencies. Thicker cortex in frontal and parietal brain
                      regions was associated with fewer direction errors in the
                      antisaccade task in female but not in male participants.
                      Thicker cortex in the calcarine sulcus was associated with
                      better smooth pursuit performance. Cerebellar gray and white
                      matter volumes were associated with better performance on
                      the antisaccade and smooth pursuit tasks. Mediation analyses
                      suggested that age-related differences in brain structures
                      explain up to $18\%$ of age-related differences in
                      oculomotor performance.Our findings extend previous studies
                      by identifying novel brain structural correlates of EM
                      performance and quantifying the extent to which they explain
                      age-related differences in EM performance. Our results show
                      that differences in brain structure partly account for
                      age-related differences in EM performance.},
      keywords     = {Humans / Male / Female / Aged / Middle Aged / Aged, 80 and
                      over / Adult / Aging: physiology / Aging: pathology /
                      Magnetic Resonance Imaging / Eye Movements: physiology /
                      Cerebral Cortex: diagnostic imaging / Cerebral Cortex:
                      anatomy $\&$ histology / Saccades: physiology / Brain /
                      Brain Cortical Thickness / Globus Pallidus: diagnostic
                      imaging / Thalamus: diagnostic imaging / Biomarkers (Other)
                      / Cognition (Other) / Epidemiology (Other) / Mediation
                      analysis (Other) / Neuroimaging (Other)},
      cin          = {AG Breteler / AG Reuter},
      ddc          = {570},
      cid          = {I:(DE-2719)1012001 / I:(DE-2719)1040310},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40498586},
      doi          = {10.1093/geronb/gbaf098},
      url          = {https://pub.dzne.de/record/280114},
}