TY  - JOUR
AU  - Russell, Lucy Louise
AU  - Bouzigues, Arabella
AU  - Convery, Rhian S
AU  - Foster, Phoebe H
AU  - Ferry-Bolder, Eve
AU  - Cash, David M
AU  - Van Swieten, John C
AU  - Jiskoot, Lize Corrine
AU  - Seelaar, Harro
AU  - Moreno, Fermin
AU  - Sánchez-Valle, Raquel
AU  - Laforce, Robert
AU  - Graff, Caroline
AU  - Masellis, Mario
AU  - Tartaglia, Maria Carmela
AU  - Rowe, James B
AU  - Borroni, Barbara
AU  - Finger, Elizabeth
AU  - Synofzik, Matthis
AU  - Galimberti, Daniela
AU  - Vandenberghe, Rik
AU  - de Mendonça, Alexandre
AU  - Butler, Christopher
AU  - Gerhard, Alexander
AU  - Ducharme, Simon
AU  - Le Ber, Isabelle
AU  - Santana, Isabel
AU  - Pasquier, Florence
AU  - Levin, Johannes
AU  - Sorbi, Sandro
AU  - Otto, Markus
AU  - Rohrer, Jonathan Daniel
TI  - Executive Function Deficits in Genetic Frontotemporal Dementia: Results From the GENFI Study.
JO  - Neurology / Genetics
VL  - 11
IS  - 4
SN  - 2376-7839
CY  - Minneapolis, Minn.
PB  - [Verlag nicht ermittelbar]
M1  - DZNE-2025-00898
SP  - e200248
PY  - 2025
AB  - Executive dysfunction is a core feature of frontotemporal dementia (FTD). While there has been extensive research into such impairments in sporadic FTD, there has been little research in the familial forms.Seven hundred fifty-two individuals were recruited in total: 214 C9orf72; 205 progranulin (GRN) and 86 microtubule associated protein tau (MAPT) mutation carriers, stratified into asymptomatic, prodromal, and fully symptomatic; and 247 mutation-negative controls. Attention and executive function were measured using the Weschler Memory Scale-Revised (WMS-R) Digit Span Backwards (DSB), Wechsler Adult Intelligence Scale-Revised Digit Symbol task, Trail Making Test Parts A and B, and the Delis-Kaplan Executive Function System Color Word Interference Test. Linear regression models with bootstrapping were used to assess differences between groups. Correlation of task score with disease severity was also performed, as well as an analysis of the neuroanatomical correlates of each task.Fully symptomatic C9orf72, GRN, and MAPT mutation carriers were significantly impaired on all tasks compared with controls (all p < 0.001), except on the WMS-R DSB in the MAPT mutation carriers (p = 0.147). While asymptomatic and prodromal C9orf72 individuals also demonstrated differences compared with controls, neither the GRN or MAPT asymptomatic or prodromal mutation carriers showed significant deficits. All tasks were significantly correlated with disease severity in each of the genetic groups (all p < 0.001).Some individuals with C9orf72 mutations show difficulties with executive function from very early on in the disease and this continues to deteriorate with disease severity. By contrast, similar difficulties occur only in the later stages of the disease in GRN and MAPT mutation carriers. This differential performance across the genetic groups will be important in neuropsychological task selection in upcoming clinical trials.
LB  - PUB:(DE-HGF)16
C6  - pmid:40703202
C2  - pmc:PMC12285671
DO  - DOI:10.1212/NXG.0000000000200248
UR  - https://pub.dzne.de/record/280115
ER  -