%0 Journal Article
%A Halbgebauer, Steffen
%A Klose, Veronika
%A Fazeli, Badrieh
%A Klassen, Paula Cynthia
%A Alexudis, Christoforos
%A Nagel, Gabriele
%A Rosenbohm, Angela
%A Rothenbacher, Dietrich
%A Gomez de San Jose, Nerea
%A Witzel, Simon
%A Elmas, Zeynep
%A Wiesenfarth, Maximilian
%A Schuster, Joachim
%A Dorst, Johannes
%A Huss, Andre
%A Bachhuber, Franziska
%A Otto, Markus
%A Landwehrmeyer, Georg Bernhard
%A Ludolph, Albert C
%A Tumani, Hayrettin
%T Neurofilament light chain reference values in serum and cerebrospinal fluid: a bi-compartmental analysis in neurological diseases.
%J Journal of neurology
%V 272
%N 8
%@ 0367-004X
%C [Darmstadt]
%I Steinkopff
%M DZNE-2025-00899
%P 535
%D 2025
%X Concentrations of neurofilament light chain (NfL), a neuroaxonal damage marker, increase with age. Therefore, age-dependent reference values are important in clinical practice. However, so far these have only been established with a bead-based system and age-dependent z-scores for CSF are missing. In addition, we here propose how the combined analysis of CSF and serum NfL could help in the discrimination between central (CNS) and peripheral nervous system (PNS) axonal degeneration.For the calculation of age reference values, serum and CSF NfL concentrations from 1,514 control subjects, measured using the microfluidic Ella system, were applied.Age-dependent NfL levels were calculated with additive quantile regression and presented with percentiles and z-scores. We observed a non-linear increase of NfL in serum and CSF. The spearman r of the association with age was 0.81 (95
%K Humans
%K Neurofilament Proteins: blood
%K Neurofilament Proteins: cerebrospinal fluid
%K Male
%K Female
%K Middle Aged
%K Adult
%K Aged
%K Reference Values
%K Young Adult
%K Nervous System Diseases: blood
%K Nervous System Diseases: cerebrospinal fluid
%K Nervous System Diseases: diagnosis
%K Adolescent
%K Aged, 80 and over
%K Child
%K Biomarkers: blood
%K Biomarkers: cerebrospinal fluid
%K Child, Preschool
%K Aging: blood
%K Aging: cerebrospinal fluid
%K Age reference values (Other)
%K Bi-compartment model (Other)
%K CSF (Other)
%K Neurofilament (Other)
%K NfL (Other)
%K Serum (Other)
%K Z-score (Other)
%K Neurofilament Proteins (NLM Chemicals)
%K neurofilament protein L (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40711597
%R 10.1007/s00415-025-13271-1
%U https://pub.dzne.de/record/280116