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000280116 0247_ $$2ISSN$$a0340-5354
000280116 0247_ $$2ISSN$$a1432-1459
000280116 037__ $$aDZNE-2025-00899
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000280116 1001_ $$0P:(DE-2719)9002026$$aHalbgebauer, Steffen$$b0$$eFirst author$$udzne
000280116 245__ $$aNeurofilament light chain reference values in serum and cerebrospinal fluid: a bi-compartmental analysis in neurological diseases.
000280116 260__ $$a[Darmstadt]$$bSteinkopff$$c2025
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000280116 520__ $$aConcentrations of neurofilament light chain (NfL), a neuroaxonal damage marker, increase with age. Therefore, age-dependent reference values are important in clinical practice. However, so far these have only been established with a bead-based system and age-dependent z-scores for CSF are missing. In addition, we here propose how the combined analysis of CSF and serum NfL could help in the discrimination between central (CNS) and peripheral nervous system (PNS) axonal degeneration.For the calculation of age reference values, serum and CSF NfL concentrations from 1,514 control subjects, measured using the microfluidic Ella system, were applied.Age-dependent NfL levels were calculated with additive quantile regression and presented with percentiles and z-scores. We observed a non-linear increase of NfL in serum and CSF. The spearman r of the association with age was 0.81 (95% CI 0.78-0.83), p < 0.0001 and 0.82 (95% CI 0.79-0.85), p < 0.0001 for serum and CSF NfL, respectively. Serum and CSF NfL levels were also associated with each other (r = 0.68 (95%CI 0.62-0.73), p < 0.0001). Furthermore, we used this association to establish a bi-compartmental CSF and serum NfL model allowing to differentiate between peripheral or central origin of neurodegeneration.The age reference curves corroborate findings of an exponential elevation of NfL in serum and CSF with increasing age. As NfL values from different platforms are not interchangeable, this is of additional high relevance. Moreover, the association between CSF and serum NfL values could be applied for clinical use regarding overlapping symptoms of CNS and PNS-based neurological diseases.
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000280116 650_7 $$2Other$$aAge reference values
000280116 650_7 $$2Other$$aBi-compartment model
000280116 650_7 $$2Other$$aCSF
000280116 650_7 $$2Other$$aNeurofilament
000280116 650_7 $$2Other$$aNfL
000280116 650_7 $$2Other$$aSerum
000280116 650_7 $$2Other$$aZ-score
000280116 650_7 $$2NLM Chemicals$$aNeurofilament Proteins
000280116 650_7 $$2NLM Chemicals$$aneurofilament protein L
000280116 650_7 $$2NLM Chemicals$$aBiomarkers
000280116 650_2 $$2MeSH$$aHumans
000280116 650_2 $$2MeSH$$aNeurofilament Proteins: blood
000280116 650_2 $$2MeSH$$aNeurofilament Proteins: cerebrospinal fluid
000280116 650_2 $$2MeSH$$aMale
000280116 650_2 $$2MeSH$$aFemale
000280116 650_2 $$2MeSH$$aMiddle Aged
000280116 650_2 $$2MeSH$$aAdult
000280116 650_2 $$2MeSH$$aAged
000280116 650_2 $$2MeSH$$aReference Values
000280116 650_2 $$2MeSH$$aYoung Adult
000280116 650_2 $$2MeSH$$aNervous System Diseases: blood
000280116 650_2 $$2MeSH$$aNervous System Diseases: cerebrospinal fluid
000280116 650_2 $$2MeSH$$aNervous System Diseases: diagnosis
000280116 650_2 $$2MeSH$$aAdolescent
000280116 650_2 $$2MeSH$$aAged, 80 and over
000280116 650_2 $$2MeSH$$aChild
000280116 650_2 $$2MeSH$$aBiomarkers: blood
000280116 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000280116 650_2 $$2MeSH$$aChild, Preschool
000280116 650_2 $$2MeSH$$aAging: blood
000280116 650_2 $$2MeSH$$aAging: cerebrospinal fluid
000280116 7001_ $$0P:(DE-2719)9001084$$aKlose, Veronika$$b1$$udzne
000280116 7001_ $$0P:(DE-HGF)0$$aFazeli, Badrieh$$b2
000280116 7001_ $$0P:(DE-2719)9001969$$aKlassen, Paula Cynthia$$b3
000280116 7001_ $$0P:(DE-2719)9001941$$aAlexudis, Christoforos$$b4$$udzne
000280116 7001_ $$0P:(DE-HGF)0$$aNagel, Gabriele$$b5
000280116 7001_ $$0P:(DE-2719)9002269$$aRosenbohm, Angela$$b6
000280116 7001_ $$0P:(DE-2719)9002270$$aRothenbacher, Dietrich$$b7
000280116 7001_ $$0P:(DE-HGF)0$$aGomez de San Jose, Nerea$$b8
000280116 7001_ $$0P:(DE-2719)9001976$$aWitzel, Simon$$b9
000280116 7001_ $$0P:(DE-HGF)0$$aElmas, Zeynep$$b10
000280116 7001_ $$0P:(DE-HGF)0$$aWiesenfarth, Maximilian$$b11
000280116 7001_ $$0P:(DE-2719)9002279$$aSchuster, Joachim$$b12$$udzne
000280116 7001_ $$0P:(DE-2719)9001951$$aDorst, Johannes$$b13$$udzne
000280116 7001_ $$0P:(DE-2719)9002029$$aHuss, Andre$$b14
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000280116 7001_ $$0P:(DE-2719)9003425$$aLandwehrmeyer, Georg Bernhard$$b17$$udzne
000280116 7001_ $$0P:(DE-2719)2812633$$aLudolph, Albert C$$b18$$udzne
000280116 7001_ $$0P:(DE-2719)9002007$$aTumani, Hayrettin$$b19$$udzne
000280116 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-025-13271-1$$gVol. 272, no. 8, p. 535$$n8$$p535$$tJournal of neurology$$v272$$x0367-004X$$y2025
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