TY  - JOUR
AU  - Halbgebauer, Steffen
AU  - Klose, Veronika
AU  - Fazeli, Badrieh
AU  - Klassen, Paula Cynthia
AU  - Alexudis, Christoforos
AU  - Nagel, Gabriele
AU  - Rosenbohm, Angela
AU  - Rothenbacher, Dietrich
AU  - Gomez de San Jose, Nerea
AU  - Witzel, Simon
AU  - Elmas, Zeynep
AU  - Wiesenfarth, Maximilian
AU  - Schuster, Joachim
AU  - Dorst, Johannes
AU  - Huss, Andre
AU  - Bachhuber, Franziska
AU  - Otto, Markus
AU  - Landwehrmeyer, Georg Bernhard
AU  - Ludolph, Albert C
AU  - Tumani, Hayrettin
TI  - Neurofilament light chain reference values in serum and cerebrospinal fluid: a bi-compartmental analysis in neurological diseases.
JO  - Journal of neurology
VL  - 272
IS  - 8
SN  - 0367-004X
CY  - [Darmstadt]
PB  - Steinkopff
M1  - DZNE-2025-00899
SP  - 535
PY  - 2025
AB  - Concentrations of neurofilament light chain (NfL), a neuroaxonal damage marker, increase with age. Therefore, age-dependent reference values are important in clinical practice. However, so far these have only been established with a bead-based system and age-dependent z-scores for CSF are missing. In addition, we here propose how the combined analysis of CSF and serum NfL could help in the discrimination between central (CNS) and peripheral nervous system (PNS) axonal degeneration.For the calculation of age reference values, serum and CSF NfL concentrations from 1,514 control subjects, measured using the microfluidic Ella system, were applied.Age-dependent NfL levels were calculated with additive quantile regression and presented with percentiles and z-scores. We observed a non-linear increase of NfL in serum and CSF. The spearman r of the association with age was 0.81 (95
KW  - Humans
KW  - Neurofilament Proteins: blood
KW  - Neurofilament Proteins: cerebrospinal fluid
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Adult
KW  - Aged
KW  - Reference Values
KW  - Young Adult
KW  - Nervous System Diseases: blood
KW  - Nervous System Diseases: cerebrospinal fluid
KW  - Nervous System Diseases: diagnosis
KW  - Adolescent
KW  - Aged, 80 and over
KW  - Child
KW  - Biomarkers: blood
KW  - Biomarkers: cerebrospinal fluid
KW  - Child, Preschool
KW  - Aging: blood
KW  - Aging: cerebrospinal fluid
KW  - Age reference values (Other)
KW  - Bi-compartment model (Other)
KW  - CSF (Other)
KW  - Neurofilament (Other)
KW  - NfL (Other)
KW  - Serum (Other)
KW  - Z-score (Other)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40711597
DO  - DOI:10.1007/s00415-025-13271-1
UR  - https://pub.dzne.de/record/280116
ER  -