Home > Publications Database > Neurofilament light chain reference values in serum and cerebrospinal fluid: a bi-compartmental analysis in neurological diseases. > print

001     280116
005     20250822101710.0
024 7 _ |a 10.1007/s00415-025-13271-1
|2 doi
024 7 _ |a pmid:40711597
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024 7 _ |a 0367-004X
|2 ISSN
024 7 _ |a 0012-1037
|2 ISSN
024 7 _ |a 0340-5354
|2 ISSN
024 7 _ |a 1432-1459
|2 ISSN
037 _ _ |a DZNE-2025-00899
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Halbgebauer, Steffen
|0 P:(DE-2719)9002026
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245 _ _ |a Neurofilament light chain reference values in serum and cerebrospinal fluid: a bi-compartmental analysis in neurological diseases.
260 _ _ |a [Darmstadt]
|c 2025
|b Steinkopff
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Concentrations of neurofilament light chain (NfL), a neuroaxonal damage marker, increase with age. Therefore, age-dependent reference values are important in clinical practice. However, so far these have only been established with a bead-based system and age-dependent z-scores for CSF are missing. In addition, we here propose how the combined analysis of CSF and serum NfL could help in the discrimination between central (CNS) and peripheral nervous system (PNS) axonal degeneration.For the calculation of age reference values, serum and CSF NfL concentrations from 1,514 control subjects, measured using the microfluidic Ella system, were applied.Age-dependent NfL levels were calculated with additive quantile regression and presented with percentiles and z-scores. We observed a non-linear increase of NfL in serum and CSF. The spearman r of the association with age was 0.81 (95% CI 0.78-0.83), p < 0.0001 and 0.82 (95% CI 0.79-0.85), p < 0.0001 for serum and CSF NfL, respectively. Serum and CSF NfL levels were also associated with each other (r = 0.68 (95%CI 0.62-0.73), p < 0.0001). Furthermore, we used this association to establish a bi-compartmental CSF and serum NfL model allowing to differentiate between peripheral or central origin of neurodegeneration.The age reference curves corroborate findings of an exponential elevation of NfL in serum and CSF with increasing age. As NfL values from different platforms are not interchangeable, this is of additional high relevance. Moreover, the association between CSF and serum NfL values could be applied for clinical use regarding overlapping symptoms of CNS and PNS-based neurological diseases.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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650 _ 7 |a Age reference values
|2 Other
650 _ 7 |a Bi-compartment model
|2 Other
650 _ 7 |a CSF
|2 Other
650 _ 7 |a Neurofilament
|2 Other
650 _ 7 |a NfL
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650 _ 7 |a Serum
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650 _ 7 |a Z-score
|2 Other
650 _ 7 |a Neurofilament Proteins
|2 NLM Chemicals
650 _ 7 |a neurofilament protein L
|2 NLM Chemicals
650 _ 7 |a Biomarkers
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Neurofilament Proteins: blood
|2 MeSH
650 _ 2 |a Neurofilament Proteins: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Reference Values
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a Nervous System Diseases: blood
|2 MeSH
650 _ 2 |a Nervous System Diseases: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Nervous System Diseases: diagnosis
|2 MeSH
650 _ 2 |a Adolescent
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Child
|2 MeSH
650 _ 2 |a Biomarkers: blood
|2 MeSH
650 _ 2 |a Biomarkers: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Child, Preschool
|2 MeSH
650 _ 2 |a Aging: blood
|2 MeSH
650 _ 2 |a Aging: cerebrospinal fluid
|2 MeSH
700 1 _ |a Klose, Veronika
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700 1 _ |a Fazeli, Badrieh
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700 1 _ |a Klassen, Paula Cynthia
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700 1 _ |a Alexudis, Christoforos
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700 1 _ |a Nagel, Gabriele
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700 1 _ |a Rosenbohm, Angela
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700 1 _ |a Rothenbacher, Dietrich
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700 1 _ |a Gomez de San Jose, Nerea
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700 1 _ |a Witzel, Simon
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700 1 _ |a Elmas, Zeynep
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700 1 _ |a Wiesenfarth, Maximilian
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700 1 _ |a Schuster, Joachim
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700 1 _ |a Dorst, Johannes
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700 1 _ |a Huss, Andre
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700 1 _ |a Bachhuber, Franziska
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700 1 _ |a Otto, Markus
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700 1 _ |a Landwehrmeyer, Georg Bernhard
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700 1 _ |a Ludolph, Albert C
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700 1 _ |a Tumani, Hayrettin
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773 _ _ |a 10.1007/s00415-025-13271-1
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|t Journal of neurology
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