%0 Journal Article
%A Ossenkoppele, Rik
%A Coomans, Emma M
%A Apostolova, Liana G
%A Baker, Suzanne L
%A Barthel, Henryk
%A Beach, Thomas G
%A Benzinger, Tammy L S
%A Betthauser, Tobey
%A Bischof, Gérard N
%A Bottlaender, Michel
%A Bourgeat, Pierick
%A den Braber, Anouk
%A Brendel, Matthias
%A Brickman, Adam M
%A Cash, David M
%A Carrillo, Maria C
%A Coath, William
%A Christian, Bradley T
%A Dickerson, Brad C
%A Dore, Vincent
%A Drzezga, Alexander
%A Feizpour, Azadeh
%A van der Flier, Wiesje M
%A Franzmeier, Nicolai
%A Frisoni, Giovanni B
%A Garibotto, Valentina
%A van de Giessen, Elsmarieke
%A Domingo-Gispert, Juan
%A Gnoerich, Johannes
%A Gu, Yuna
%A Guan, Yihui
%A Hanseeuw, Bernard J
%A Harrison, Theresa M
%A Jack, Clifford R
%A Jaeger, Elena
%A Jagust, William J
%A Jansen, Willemijn J
%A La Joie, Renaud
%A Johnson, Keith A
%A Johnson, Sterling C
%A Kennedy, Ian A
%A Kim, Jun Pyo
%A van Laere, Koen
%A Lagarde, Julien
%A Lao, Patrick
%A Luchsinger, José A
%A Kern, Silke
%A Kreisl, William C
%A Malotaux, Vincent
%A Malpetti, Maura
%A Manly, Jennifer J
%A Mao, Xiaoxie
%A Mattsson-Carlgren, Niklas
%A Messerschmidt, Konstantin
%A Minguillon, Carolina
%A Mormino, Elizabeth M
%A O'Brien, John T
%A Palmqvist, Sebastian
%A Peretti, Debora E
%A Petersen, Ron C
%A Pijnenburg, Yolande A L
%A Pontecorvo, Michael J
%A Poirier, Judes
%A Rabinovici, Gil D
%A Rahmouni, Nesrine
%A Risacher, Shannon L
%A Rosa-Neto, Pedro
%A Rosen, Howard
%A Rowe, Christopher C
%A Rowe, James B
%A Rullmann, Michael
%A Salman, Yasmine
%A Sarazin, Marie
%A Saykin, Andrew J
%A Schneider, Julie A
%A Schöll, Michael
%A Schott, Jonathan M
%A Seo, Sang Won
%A Serrano, Geidy E
%A Shcherbinin, Sergey
%A Shekari, Mahnaz
%A Skoog, Ingmar
%A Smith, Ruben
%A Sperling, Reisa A
%A Spruyt, Laure
%A Stomrud, Erik
%A Strandberg, Olof
%A Therriault, Joseph
%A Xie, Fang
%A Vandenberghe, Rik
%A Villemagne, Victor L
%A Villeneuve, Sylvia
%A Visser, Pieter Jelle
%A Vossler, Hillary
%A Young, Christina B
%A Groot, Colin
%A Hansson, Oskar
%T Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
%J Nature neuroscience
%V 28
%N 8
%@ 1097-6256
%C New York, NY
%I Nature America
%M DZNE-2025-00900
%P 1610 - 1621
%D 2025
%X Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive impairment (MCI) and 2,477 participants with dementia. We found that from age 60 years to 80 years, tau PET positivity in a temporal composite region increased from 1.1
%K Humans
%K Female
%K Male
%K Positron-Emission Tomography
%K Amyloid beta-Peptides: metabolism
%K Amyloid beta-Peptides: genetics
%K tau Proteins: metabolism
%K Aged
%K Middle Aged
%K Aged, 80 and over
%K Cognitive Dysfunction: genetics
%K Cognitive Dysfunction: diagnostic imaging
%K Cognitive Dysfunction: metabolism
%K Apolipoproteins E: genetics
%K Genotype
%K Age Factors
%K Cohort Studies
%K Sex Factors
%K Amyloid beta-Peptides (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K Apolipoproteins E (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40670684
%2 pmc:PMC12321570
%R 10.1038/s41593-025-02000-6
%U https://pub.dzne.de/record/280222