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000280222 0247_ $$2doi$$a10.1038/s41593-025-02000-6
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000280222 041__ $$aEnglish
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000280222 1001_ $$00000-0003-1584-7477$$aOssenkoppele, Rik$$b0
000280222 245__ $$aTau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
000280222 260__ $$aNew York, NY$$bNature America$$c2025
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000280222 520__ $$aTau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive impairment (MCI) and 2,477 participants with dementia. We found that from age 60 years to 80 years, tau PET positivity in a temporal composite region increased from 1.1% to 4.4% among CU amyloid-β (Aβ)-negative participants and from 17.4% to 22.2% among CU Aβ-positive participants. Across the same age span, tau PET positivity decreased from 68.0% to 52.9% in participants with MCI and from 91.5% to 74.6% in participants with dementia. Age, Aβ status, APOE ε4 carriership and female sex were all associated with a higher prevalence of tau PET positivity across groups. APOE ε4 carriership in CU individuals lowered the age at onset of both Aβ positivity and tau positivity by decades. Finally, we replicated these associations in an independent autopsy dataset (N = 5,072 from 3 cohorts).
000280222 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
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000280222 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000280222 650_7 $$2NLM Chemicals$$atau Proteins
000280222 650_7 $$2NLM Chemicals$$aApolipoproteins E
000280222 650_2 $$2MeSH$$aHumans
000280222 650_2 $$2MeSH$$aFemale
000280222 650_2 $$2MeSH$$aMale
000280222 650_2 $$2MeSH$$aPositron-Emission Tomography
000280222 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000280222 650_2 $$2MeSH$$aAmyloid beta-Peptides: genetics
000280222 650_2 $$2MeSH$$atau Proteins: metabolism
000280222 650_2 $$2MeSH$$aAged
000280222 650_2 $$2MeSH$$aMiddle Aged
000280222 650_2 $$2MeSH$$aAged, 80 and over
000280222 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000280222 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000280222 650_2 $$2MeSH$$aCognitive Dysfunction: metabolism
000280222 650_2 $$2MeSH$$aApolipoproteins E: genetics
000280222 650_2 $$2MeSH$$aGenotype
000280222 650_2 $$2MeSH$$aAge Factors
000280222 650_2 $$2MeSH$$aCohort Studies
000280222 650_2 $$2MeSH$$aSex Factors
000280222 7001_ $$aCoomans, Emma M$$b1
000280222 7001_ $$aApostolova, Liana G$$b2
000280222 7001_ $$aBaker, Suzanne L$$b3
000280222 7001_ $$aBarthel, Henryk$$b4
000280222 7001_ $$aBeach, Thomas G$$b5
000280222 7001_ $$00000-0002-8114-0552$$aBenzinger, Tammy L S$$b6
000280222 7001_ $$00000-0001-8856-1352$$aBetthauser, Tobey$$b7
000280222 7001_ $$aBischof, Gérard N$$b8
000280222 7001_ $$00000-0002-2890-3653$$aBottlaender, Michel$$b9
000280222 7001_ $$00000-0002-2605-4766$$aBourgeat, Pierick$$b10
000280222 7001_ $$aden Braber, Anouk$$b11
000280222 7001_ $$0P:(DE-2719)9001539$$aBrendel, Matthias$$b12
000280222 7001_ $$00000-0002-5125-8226$$aBrickman, Adam M$$b13
000280222 7001_ $$00000-0001-7833-616X$$aCash, David M$$b14
000280222 7001_ $$aCarrillo, Maria C$$b15
000280222 7001_ $$aCoath, William$$b16
000280222 7001_ $$00000-0002-9653-559X$$aChristian, Bradley T$$b17
000280222 7001_ $$00000-0002-5958-3445$$aDickerson, Brad C$$b18
000280222 7001_ $$00000-0002-8051-0558$$aDore, Vincent$$b19
000280222 7001_ $$0P:(DE-2719)2811239$$aDrzezga, Alexander$$b20
000280222 7001_ $$00000-0003-0826-4011$$aFeizpour, Azadeh$$b21
000280222 7001_ $$00000-0001-8766-6224$$avan der Flier, Wiesje M$$b22
000280222 7001_ $$00000-0001-9736-2283$$aFranzmeier, Nicolai$$b23
000280222 7001_ $$aFrisoni, Giovanni B$$b24
000280222 7001_ $$aGaribotto, Valentina$$b25
000280222 7001_ $$00000-0001-9956-4233$$avan de Giessen, Elsmarieke$$b26
000280222 7001_ $$aDomingo-Gispert, Juan$$b27
000280222 7001_ $$0P:(DE-2719)9001652$$aGnoerich, Johannes$$b28$$udzne
000280222 7001_ $$aGu, Yuna$$b29
000280222 7001_ $$aGuan, Yihui$$b30
000280222 7001_ $$aHanseeuw, Bernard J$$b31
000280222 7001_ $$aHarrison, Theresa M$$b32
000280222 7001_ $$00000-0001-7916-622X$$aJack, Clifford R$$b33
000280222 7001_ $$00009-0007-9387-3175$$aJaeger, Elena$$b34
000280222 7001_ $$00000-0002-4458-113X$$aJagust, William J$$b35
000280222 7001_ $$aJansen, Willemijn J$$b36
000280222 7001_ $$00000-0003-2581-8100$$aLa Joie, Renaud$$b37
000280222 7001_ $$aJohnson, Keith A$$b38
000280222 7001_ $$00000-0002-8501-545X$$aJohnson, Sterling C$$b39
000280222 7001_ $$aKennedy, Ian A$$b40
000280222 7001_ $$00000-0003-4376-3107$$aKim, Jun Pyo$$b41
000280222 7001_ $$00000-0001-5200-7245$$avan Laere, Koen$$b42
000280222 7001_ $$00000-0002-2018-261X$$aLagarde, Julien$$b43
000280222 7001_ $$aLao, Patrick$$b44
000280222 7001_ $$aLuchsinger, José A$$b45
000280222 7001_ $$aKern, Silke$$b46
000280222 7001_ $$aKreisl, William C$$b47
000280222 7001_ $$aMalotaux, Vincent$$b48
000280222 7001_ $$00000-0001-8923-9656$$aMalpetti, Maura$$b49
000280222 7001_ $$aManly, Jennifer J$$b50
000280222 7001_ $$aMao, Xiaoxie$$b51
000280222 7001_ $$00000-0002-8885-7724$$aMattsson-Carlgren, Niklas$$b52
000280222 7001_ $$aAging, Mayo Clinic Study on$$b53$$eCollaboration Author
000280222 7001_ $$aMesserschmidt, Konstantin$$b54
000280222 7001_ $$aMinguillon, Carolina$$b55
000280222 7001_ $$aMormino, Elizabeth M$$b56
000280222 7001_ $$00000-0002-0837-5080$$aO'Brien, John T$$b57
000280222 7001_ $$00000-0002-9267-1930$$aPalmqvist, Sebastian$$b58
000280222 7001_ $$00000-0002-3033-8817$$aPeretti, Debora E$$b59
000280222 7001_ $$00000-0002-8178-6601$$aPetersen, Ron C$$b60
000280222 7001_ $$aPijnenburg, Yolande A L$$b61
000280222 7001_ $$aPontecorvo, Michael J$$b62
000280222 7001_ $$00000-0002-8018-4545$$aPoirier, Judes$$b63
000280222 7001_ $$aGroup, PREVENT-AD Research$$b64$$eCollaboration Author
000280222 7001_ $$00000-0002-3626-4265$$aRabinovici, Gil D$$b65
000280222 7001_ $$aRahmouni, Nesrine$$b66
000280222 7001_ $$00000-0002-3304-7943$$aRisacher, Shannon L$$b67
000280222 7001_ $$00000-0001-9116-1376$$aRosa-Neto, Pedro$$b68
000280222 7001_ $$aRosen, Howard$$b69
000280222 7001_ $$00000-0003-3910-2453$$aRowe, Christopher C$$b70
000280222 7001_ $$00000-0001-7216-8679$$aRowe, James B$$b71
000280222 7001_ $$aRullmann, Michael$$b72
000280222 7001_ $$00000-0002-8564-5136$$aSalman, Yasmine$$b73
000280222 7001_ $$aSarazin, Marie$$b74
000280222 7001_ $$00000-0002-1376-8532$$aSaykin, Andrew J$$b75
000280222 7001_ $$00000-0002-9482-1752$$aSchneider, Julie A$$b76
000280222 7001_ $$00000-0001-7800-1781$$aSchöll, Michael$$b77
000280222 7001_ $$00000-0003-2059-024X$$aSchott, Jonathan M$$b78
000280222 7001_ $$aSeo, Sang Won$$b79
000280222 7001_ $$aSerrano, Geidy E$$b80
000280222 7001_ $$aShcherbinin, Sergey$$b81
000280222 7001_ $$aShekari, Mahnaz$$b82
000280222 7001_ $$aSkoog, Ingmar$$b83
000280222 7001_ $$00000-0001-7147-0112$$aSmith, Ruben$$b84
000280222 7001_ $$aSperling, Reisa A$$b85
000280222 7001_ $$00000-0002-0618-5005$$aSpruyt, Laure$$b86
000280222 7001_ $$aStomrud, Erik$$b87
000280222 7001_ $$aStrandberg, Olof$$b88
000280222 7001_ $$aTherriault, Joseph$$b89
000280222 7001_ $$00000-0003-2667-281X$$aXie, Fang$$b90
000280222 7001_ $$00000-0001-6237-2502$$aVandenberghe, Rik$$b91
000280222 7001_ $$aVillemagne, Victor L$$b92
000280222 7001_ $$00000-0003-2338-0467$$aVilleneuve, Sylvia$$b93
000280222 7001_ $$00000-0001-8008-9727$$aVisser, Pieter Jelle$$b94
000280222 7001_ $$00009-0007-8693-1939$$aVossler, Hillary$$b95
000280222 7001_ $$aYoung, Christina B$$b96
000280222 7001_ $$aGroot, Colin$$b97
000280222 7001_ $$00000-0001-8467-7286$$aHansson, Oskar$$b98
000280222 7001_ $$aPetersen, Ron C$$b99$$eContributor
000280222 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-025-02000-6$$gVol. 28, no. 8, p. 1610 - 1621$$n8$$p1610 - 1621$$tNature neuroscience$$v28$$x1097-6256$$y2025
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