% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ossenkoppele:280222,
      author       = {Ossenkoppele, Rik and Coomans, Emma M and Apostolova, Liana
                      G and Baker, Suzanne L and Barthel, Henryk and Beach, Thomas
                      G and Benzinger, Tammy L S and Betthauser, Tobey and
                      Bischof, Gérard N and Bottlaender, Michel and Bourgeat,
                      Pierick and den Braber, Anouk and Brendel, Matthias and
                      Brickman, Adam M and Cash, David M and Carrillo, Maria C and
                      Coath, William and Christian, Bradley T and Dickerson, Brad
                      C and Dore, Vincent and Drzezga, Alexander and Feizpour,
                      Azadeh and van der Flier, Wiesje M and Franzmeier, Nicolai
                      and Frisoni, Giovanni B and Garibotto, Valentina and van de
                      Giessen, Elsmarieke and Domingo-Gispert, Juan and Gnoerich,
                      Johannes and Gu, Yuna and Guan, Yihui and Hanseeuw, Bernard
                      J and Harrison, Theresa M and Jack, Clifford R and Jaeger,
                      Elena and Jagust, William J and Jansen, Willemijn J and La
                      Joie, Renaud and Johnson, Keith A and Johnson, Sterling C
                      and Kennedy, Ian A and Kim, Jun Pyo and van Laere, Koen and
                      Lagarde, Julien and Lao, Patrick and Luchsinger, José A and
                      Kern, Silke and Kreisl, William C and Malotaux, Vincent and
                      Malpetti, Maura and Manly, Jennifer J and Mao, Xiaoxie and
                      Mattsson-Carlgren, Niklas and Messerschmidt, Konstantin and
                      Minguillon, Carolina and Mormino, Elizabeth M and O'Brien,
                      John T and Palmqvist, Sebastian and Peretti, Debora E and
                      Petersen, Ron C and Pijnenburg, Yolande A L and Pontecorvo,
                      Michael J and Poirier, Judes and Rabinovici, Gil D and
                      Rahmouni, Nesrine and Risacher, Shannon L and Rosa-Neto,
                      Pedro and Rosen, Howard and Rowe, Christopher C and Rowe,
                      James B and Rullmann, Michael and Salman, Yasmine and
                      Sarazin, Marie and Saykin, Andrew J and Schneider, Julie A
                      and Schöll, Michael and Schott, Jonathan M and Seo, Sang
                      Won and Serrano, Geidy E and Shcherbinin, Sergey and
                      Shekari, Mahnaz and Skoog, Ingmar and Smith, Ruben and
                      Sperling, Reisa A and Spruyt, Laure and Stomrud, Erik and
                      Strandberg, Olof and Therriault, Joseph and Xie, Fang and
                      Vandenberghe, Rik and Villemagne, Victor L and Villeneuve,
                      Sylvia and Visser, Pieter Jelle and Vossler, Hillary and
                      Young, Christina B and Groot, Colin and Hansson, Oskar},
      collaboration = {Aging, Mayo Clinic Study on and Group, PREVENT-AD Research},
      othercontributors = {Petersen, Ron C},
      title        = {{T}au {PET} positivity in individuals with and without
                      cognitive impairment varies with age, amyloid-β status,
                      {APOE} genotype and sex.},
      journal      = {Nature neuroscience},
      volume       = {28},
      number       = {8},
      issn         = {1097-6256},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DZNE-2025-00900},
      pages        = {1610 - 1621},
      year         = {2025},
      abstract     = {Tau positron emission tomography (PET) imaging allows in
                      vivo detection of tau proteinopathy in Alzheimer's disease,
                      which is associated with neurodegeneration and cognitive
                      decline. Understanding how demographic, clinical and genetic
                      factors relate to tau PET positivity will facilitate its use
                      for clinical practice and research. Here we conducted an
                      analysis of 42 cohorts worldwide (N = 12,048), including
                      7,394 cognitively unimpaired (CU) participants, 2,177
                      participants with mild cognitive impairment (MCI) and 2,477
                      participants with dementia. We found that from age 60 years
                      to 80 years, tau PET positivity in a temporal composite
                      region increased from $1.1\%$ to $4.4\%$ among CU amyloid-β
                      (Aβ)-negative participants and from $17.4\%$ to $22.2\%$
                      among CU Aβ-positive participants. Across the same age
                      span, tau PET positivity decreased from $68.0\%$ to $52.9\%$
                      in participants with MCI and from $91.5\%$ to $74.6\%$ in
                      participants with dementia. Age, Aβ status, APOE ε4
                      carriership and female sex were all associated with a higher
                      prevalence of tau PET positivity across groups. APOE ε4
                      carriership in CU individuals lowered the age at onset of
                      both Aβ positivity and tau positivity by decades. Finally,
                      we replicated these associations in an independent autopsy
                      dataset (N = 5,072 from 3 cohorts).},
      keywords     = {Humans / Female / Male / Positron-Emission Tomography /
                      Amyloid beta-Peptides: metabolism / Amyloid beta-Peptides:
                      genetics / tau Proteins: metabolism / Aged / Middle Aged /
                      Aged, 80 and over / Cognitive Dysfunction: genetics /
                      Cognitive Dysfunction: diagnostic imaging / Cognitive
                      Dysfunction: metabolism / Apolipoproteins E: genetics /
                      Genotype / Age Factors / Cohort Studies / Sex Factors /
                      Amyloid beta-Peptides (NLM Chemicals) / tau Proteins (NLM
                      Chemicals) / Apolipoproteins E (NLM Chemicals)},
      cin          = {AG Haass / AG Boecker},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007 / I:(DE-2719)1011202},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40670684},
      pmc          = {pmc:PMC12321570},
      doi          = {10.1038/s41593-025-02000-6},
      url          = {https://pub.dzne.de/record/280222},
}