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@ARTICLE{Mietzner:280227,
      author       = {Mietzner, Grazia and Lümkemann, Lilli and Schreiber, Frank
                      and Brüggemann, Jascha and Benramadan, Abrar and Al-Dubai,
                      Marwa and Sciarra, Alessandro and Knoll, Christoph and
                      Kuehn, Esther and Speck, Oliver and Schreiber, Stefanie and
                      Mattern, Hendrik},
      title        = {{A}ssessing {A}rterial {P}atterns in the {M}otor {C}ortex
                      {W}ith 7 {T}esla {M}agnetic {R}esonance {I}maging and
                      {V}essel {D}istance {M}apping.},
      journal      = {Human brain mapping},
      volume       = {46},
      number       = {11},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2025-00905},
      pages        = {e70311},
      year         = {2025},
      abstract     = {Leveraging high-resolution 7 T magnetic resonance imaging
                      (MRI) and vessel distance mapping (VDM), the arterial supply
                      patterns and dominances of the motor cortex, which could
                      previously only be studied postmortem, were assessed in vivo
                      and fully noninvasively. Beyond vessel patterns and
                      dominances, the potential relation between the
                      vascularization and the motor cortex thickness was studied.
                      Twenty-one healthy participants underwent 7 T MRI scans to
                      map arterial supply and motor cortex at 0.45 mm isotropic
                      resolution. The motor cortex vasculature was segmented
                      manually with vessel-specific labels. VDM was utilized to
                      estimate the vessel-specific supply regions and,
                      subsequently, assess vessel patterns and dominances.
                      Statistical tests were applied to test if the vasculature
                      impacts mean motor cortical thickness estimates. Vessel
                      patterns, that is the presence of supplying vessels, were
                      classified as three-, four-, and five-vessel patterns with a
                      prevalence of $26.3\%,$ $50.0\%,$ and $23.7\%,$
                      respectively. Vessel dominance, that is the ratio of supply
                      volumes, of the ACA branches showed dominance of the
                      pericallosal artery, callosomarginal artery, and equal
                      contribution, in $34.2\%,$ $34.2\%,$ and $31.6\%$ of the
                      cases, respectively. For the MCA groups, the prevalence of
                      precentral group dominance, central group dominances, and
                      equal contribution was $13.2\%,$ $34.2\%,$ and $52.6\%,$
                      respectively. Although the central and precentral groups
                      were found in all hemispheres, the postcentral group was
                      found in $28.9\%$ of hemispheres with highly variable supply
                      contribution. Statistical tests returned no significance for
                      the effect of vessel patterns and dominances on the mean
                      motor cortex thickness. With 7 T MRI and VDM, the motor
                      cortex vascularization can be assessed fully noninvasively
                      and longitudinally while providing overall good concordance
                      with previous post mortem studies. Our comprehensive
                      analysis of arterial motor cortex vascularization showed
                      considerable variability between hemispheres, rendering the
                      usage of pattern-specific atlases and analysis more suitable
                      than single normative representations. The successful
                      translation from post mortem to in vivo enables the study of
                      vascular reserve in disorders affecting the motor cortex,
                      such as ALS, and can be translated to other brain regions
                      and neurodegenerative diseases in the future.},
      keywords     = {Humans / Motor Cortex: blood supply / Motor Cortex:
                      diagnostic imaging / Motor Cortex: anatomy $\&$ histology /
                      Male / Magnetic Resonance Imaging: methods / Female / Adult
                      / Young Adult / Cerebral Arteries: diagnostic imaging /
                      Cerebral Arteries: anatomy $\&$ histology / Image
                      Processing, Computer-Assisted / Middle Aged /
                      high‐resolution imaging (Other) / inter‐individual
                      vascular variability (Other) / motor cortex vascularization
                      (Other) / ultra‐high field (Other) / vessel atlas (Other)
                      / vessel dominance (Other) / vessel supply patterns (Other)},
      cin          = {AG Schreiber / AG Gasser / AG Düzel / AG Speck},
      ddc          = {610},
      cid          = {I:(DE-2719)1310010 / I:(DE-2719)1210000 /
                      I:(DE-2719)5000006 / I:(DE-2719)1340009},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40762423},
      pmc          = {pmc:PMC12322923},
      doi          = {10.1002/hbm.70311},
      url          = {https://pub.dzne.de/record/280227},
}