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000280228 037__ $$aDZNE-2025-00906
000280228 041__ $$aEnglish
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000280228 1001_ $$0P:(DE-2719)9001975$$aTiwari, Vini$$b0$$eFirst author$$udzne
000280228 245__ $$aLipid metabolism and neuroinflammation: What is the link?
000280228 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2025
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000280228 520__ $$aLipid metabolism is central to host defense by supporting and modulating immune cell function. Immune signaling pathways control anabolic lipid processes to drive membrane synthesis and produce bioactive lipid mediators during activation. In turn, metabolic states profoundly influence immune signaling, particularly during the resolution of inflammation. Emerging evidence highlights a dynamic interplay between lipid metabolism and neuroinflammation. A striking example is the intrinsic lipoprotein system of the central nervous system, which undergoes profound changes during pathology, with lipoproteins serving not only in lipid transport but also as immune modulators and as contributors to disease tolerance. Importantly, major neurodegenerative diseases are genetically linked to disruptions in lipid metabolism. Deciphering this complex cross talk may provide opportunities for novel therapies targeting neuroinflammatory and neurodegenerative disorders.
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000280228 650_7 $$2NLM Chemicals$$aLipoproteins
000280228 650_2 $$2MeSH$$aHumans
000280228 650_2 $$2MeSH$$aLipid Metabolism
000280228 650_2 $$2MeSH$$aAnimals
000280228 650_2 $$2MeSH$$aNeuroinflammatory Diseases: metabolism
000280228 650_2 $$2MeSH$$aNeuroinflammatory Diseases: immunology
000280228 650_2 $$2MeSH$$aNeuroinflammatory Diseases: pathology
000280228 650_2 $$2MeSH$$aInflammation: metabolism
000280228 650_2 $$2MeSH$$aNeurodegenerative Diseases: metabolism
000280228 650_2 $$2MeSH$$aNeurodegenerative Diseases: immunology
000280228 650_2 $$2MeSH$$aNeurodegenerative Diseases: pathology
000280228 650_2 $$2MeSH$$aSignal Transduction
000280228 650_2 $$2MeSH$$aLipoproteins: metabolism
000280228 650_2 $$2MeSH$$aCentral Nervous System: metabolism
000280228 650_2 $$2MeSH$$aCentral Nervous System: immunology
000280228 7001_ $$0P:(DE-2719)2811642$$aSimons, Mikael$$b1$$eLast author
000280228 773__ $$0PERI:(DE-600)1477240-1$$a10.1084/jem.20241232$$gVol. 222, no. 9, p. e20241232$$n9$$pe20241232$$tJournal of experimental medicine$$v222$$x0022-1007$$y2025
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