TY  - JOUR
AU  - Tiwari, Vini
AU  - Simons, Mikael
TI  - Lipid metabolism and neuroinflammation: What is the link?
JO  - Journal of experimental medicine
VL  - 222
IS  - 9
SN  - 0022-1007
CY  - New York, NY
PB  - Rockefeller Univ. Press
M1  - DZNE-2025-00906
SP  - e20241232
PY  - 2025
AB  - Lipid metabolism is central to host defense by supporting and modulating immune cell function. Immune signaling pathways control anabolic lipid processes to drive membrane synthesis and produce bioactive lipid mediators during activation. In turn, metabolic states profoundly influence immune signaling, particularly during the resolution of inflammation. Emerging evidence highlights a dynamic interplay between lipid metabolism and neuroinflammation. A striking example is the intrinsic lipoprotein system of the central nervous system, which undergoes profound changes during pathology, with lipoproteins serving not only in lipid transport but also as immune modulators and as contributors to disease tolerance. Importantly, major neurodegenerative diseases are genetically linked to disruptions in lipid metabolism. Deciphering this complex cross talk may provide opportunities for novel therapies targeting neuroinflammatory and neurodegenerative disorders.
KW  - Humans
KW  - Lipid Metabolism
KW  - Animals
KW  - Neuroinflammatory Diseases: metabolism
KW  - Neuroinflammatory Diseases: immunology
KW  - Neuroinflammatory Diseases: pathology
KW  - Inflammation: metabolism
KW  - Neurodegenerative Diseases: metabolism
KW  - Neurodegenerative Diseases: immunology
KW  - Neurodegenerative Diseases: pathology
KW  - Signal Transduction
KW  - Lipoproteins: metabolism
KW  - Central Nervous System: metabolism
KW  - Central Nervous System: immunology
KW  - Lipoproteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40762805
DO  - DOI:10.1084/jem.20241232
UR  - https://pub.dzne.de/record/280228
ER  -