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@ARTICLE{Tiwari:280228,
      author       = {Tiwari, Vini and Simons, Mikael},
      title        = {{L}ipid metabolism and neuroinflammation: {W}hat is the
                      link?},
      journal      = {Journal of experimental medicine},
      volume       = {222},
      number       = {9},
      issn         = {0022-1007},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {DZNE-2025-00906},
      pages        = {e20241232},
      year         = {2025},
      abstract     = {Lipid metabolism is central to host defense by supporting
                      and modulating immune cell function. Immune signaling
                      pathways control anabolic lipid processes to drive membrane
                      synthesis and produce bioactive lipid mediators during
                      activation. In turn, metabolic states profoundly influence
                      immune signaling, particularly during the resolution of
                      inflammation. Emerging evidence highlights a dynamic
                      interplay between lipid metabolism and neuroinflammation. A
                      striking example is the intrinsic lipoprotein system of the
                      central nervous system, which undergoes profound changes
                      during pathology, with lipoproteins serving not only in
                      lipid transport but also as immune modulators and as
                      contributors to disease tolerance. Importantly, major
                      neurodegenerative diseases are genetically linked to
                      disruptions in lipid metabolism. Deciphering this complex
                      cross talk may provide opportunities for novel therapies
                      targeting neuroinflammatory and neurodegenerative
                      disorders.},
      subtyp        = {Review Article},
      keywords     = {Humans / Lipid Metabolism / Animals / Neuroinflammatory
                      Diseases: metabolism / Neuroinflammatory Diseases:
                      immunology / Neuroinflammatory Diseases: pathology /
                      Inflammation: metabolism / Neurodegenerative Diseases:
                      metabolism / Neurodegenerative Diseases: immunology /
                      Neurodegenerative Diseases: pathology / Signal Transduction
                      / Lipoproteins: metabolism / Central Nervous System:
                      metabolism / Central Nervous System: immunology /
                      Lipoproteins (NLM Chemicals)},
      cin          = {AG Simons},
      ddc          = {610},
      cid          = {I:(DE-2719)1110008},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40762805},
      doi          = {10.1084/jem.20241232},
      url          = {https://pub.dzne.de/record/280228},
}