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@ARTICLE{Sanftenberg:280231,
      author       = {Sanftenberg, Linda and Kosilek, Robert Philipp and
                      Birnberger, Lorenz and Schillok, Hannah and Wittmann, Felix
                      and Luppa, Melanie and Blawert, Anne and Boekholt, Melanie
                      and Brettschneider, Christian and König, Hans-Helmut and
                      Bauer, Alexander and Weise, Solveig and Frese, Thomas and
                      Kaduszkiewicz, Hanna and Döhring, Juliane and Escales,
                      Catharina and Thyrian, Jochen René and Wiese, Birgitt and
                      Riedel-Heller, Steffi G and Gensichen, Jochen},
      title        = {{T}wo sides of the same coin: recruitment performance and
                      perceived workload in primary care trials-insights from the
                      {A}ge{W}ell.de study.},
      journal      = {BMC primary care},
      volume       = {26},
      number       = {1},
      issn         = {1471-2296},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2025-00909},
      pages        = {243},
      year         = {2025},
      abstract     = {Recruitment through general practitioners (GPs) is a key
                      challenge in primary care trials. Understanding how
                      individual, practice, and regional characteristics affect
                      recruitment and perceived workload could help optimize
                      participation strategies. This study aims to identify
                      barriers and facilitators to patient recruitment within the
                      AgeWell.de dementia prevention trial.We analysed publicly
                      available data on GPs participating in the AgeWell.de trial,
                      including their sociodemographic characteristics, practice
                      structures, and socioeconomic indicators of their practice
                      locations, alongside recruitment and survey data. We used
                      correlation analysis and uni- and multivariable regression
                      models to explore determinants of study engagement in terms
                      of recruitment performance and perceived workload.Among 120
                      participating GPs, a total of 1,173 patients were recruited,
                      though contributions varied widely. The top $20\%$ of
                      recruiters (Q5) accounted for $42.1\%$ of all participants,
                      while the lowest quintile (Q1) recruited just $3.2\%.$ GPs
                      with a doctorate degree recruited more patients (IRR = 1.45,
                      p < 0.05). Higher perceived workload was linked to increased
                      recruitment engagement (IRR = 1.30, p < 0.1). In contrast,
                      larger practice teams were associated with lower perceived
                      workload (OR = 0.71, p < 0.1).GP recruitment performance and
                      perceived workload are closely linked, influenced by both
                      individual research interest and structural support. The
                      disproportionate recruitment burden among a small subset of
                      GPs highlights the need for strategies to engage low
                      recruiters and support high performers. Strengthening
                      practice-based research networks, could help make research
                      involvement more feasible for a wider range of GPs. Trail
                      registration: German Clinical Trials Register (DRKS; trial
                      identifier: DRKS00013555); Date of Registration:
                      2017-12-07.The online version contains supplementary
                      material available at 10.1186/s12875-025-02948-1.},
      keywords     = {Barriers and facilitators (Other) / General practitioner
                      (Other) / Patient recruitment (Other) / Practice-based
                      research networks (Other) / Randomized controlled trial
                      (Other)},
      cin          = {AG Thyrian},
      ddc          = {610},
      cid          = {I:(DE-2719)1510800},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40764906},
      pmc          = {pmc:PMC12326823},
      doi          = {10.1186/s12875-025-02948-1},
      url          = {https://pub.dzne.de/record/280231},
}