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@ARTICLE{Her:280239,
      author       = {Hüer, Theresa and Weitzel, Milena and Giebel, Godwin Denk
                      and Raszke, Pascal and Wasem, Jürgen and Levin, Johannes
                      and Nübling, Georg and Wagemann, Olivia and Wlasich,
                      Elisabeth and Pantel, Johannes and Tesky, Valentina and
                      Schall, Arthur and Walendzik, Anke},
      title        = {{A}lzheimer-{D}emenz bei {M}enschen mit einem
                      {D}own-{S}yndrom : {E}rgebnisse leitfadengestützter
                      {E}xpert:inneninterviews zu {V}ersorgungsdefiziten in
                      {D}iagnostik und {T}herapie sowie {L}ösungsansätzen |
                      {A}lzheimer's dementia in people with {D}own syndrome :
                      {R}esults of guideline-assisted expert interviews on
                      healthcare deficits in the diagnostics and treatment as well
                      as solution approaches},
      journal      = {Zeitschrift für Gerontologie und Geriatrie},
      volume       = {58},
      number       = {5},
      issn         = {0948-6704},
      address      = {Heidelberg},
      publisher    = {Springer Medizin},
      reportid     = {DZNE-2025-00917},
      pages        = {397 - 404},
      year         = {2025},
      abstract     = {People with Down syndrome have a genetically increased risk
                      of developing early onset Alzheimer's dementia. An interview
                      study with healthcare providers, patient representatives and
                      employees in residential and work facilities was conducted
                      to identify deficits in the healthcare process and
                      approaches to overcoming them.In this study 14
                      semi-structured interviews were conducted and analyzed using
                      qualitative content analysis.A lack of knowledge and
                      experience on the part of medical service providers in
                      dealing with and providing medical care for people with Down
                      syndrome was identified as a key challenge. In addition, the
                      diagnosis of dementia in people with Down syndrome is
                      difficult for various reasons (including lack of appropriate
                      diagnostic tools in standard care and lack of time or
                      financial resources). Doubts were expressed about the
                      efficacy of antidementia medications and the reasons for the
                      increased use of sedatives were discussed. Attentive
                      observation of behavior and involvement of caregivers,
                      regular review and reduction of polypharmacy and the use of
                      alternative behavior modification techniques were mentioned
                      as possible solutions.The identified deficits in the medical
                      care of the target population and the approaches to solving
                      them will be incorporated into the development of health
                      policy recommendations in order to optimize the care
                      situation of those affected in the long term.},
      keywords     = {Humans / Alzheimer Disease: diagnosis / Alzheimer Disease:
                      therapy / Alzheimer Disease: epidemiology / Down Syndrome:
                      diagnosis / Down Syndrome: therapy / Down Syndrome:
                      epidemiology / Germany: epidemiology / Male / Female /
                      Practice Guidelines as Topic / Aged / Guideline Adherence:
                      statistics $\&$ numerical data / Middle Aged / Comorbidity /
                      Interview study (Other) / Medical care (Other) / Medical
                      care deficits (Other) / Solution approaches (Other) /
                      Trisomy 21 (Other)},
      cin          = {Clinical Research (Munich) / AG Levin},
      ddc          = {150},
      cid          = {I:(DE-2719)1111015 / I:(DE-2719)1111016},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39384617},
      pmc          = {pmc:PMC12321907},
      doi          = {10.1007/s00391-024-02371-8},
      url          = {https://pub.dzne.de/record/280239},
}