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@INBOOK{Grass:280243,
      author       = {Grass, Tobias and Dokuzluoglu, Zeynep and Rodríguez-Muela,
                      Natalia},
      title        = {{N}euromuscular {O}rganoids to {S}tudy {S}pinal {C}ord
                      {D}evelopment and {D}isease.},
      volume       = {2951},
      address      = {New York, NY},
      publisher    = {Springer US},
      reportid     = {DZNE-2025-00921},
      isbn         = {978-1-0716-4681-6 (print)},
      series       = {Methods in Molecular Biology},
      pages        = {197 - 219},
      year         = {2025},
      comment      = {Organoids / Turksen, Kursad (Editor) ; New York, NY :
                      Springer US, 2025, Chapter 574 ; ISSN: 1064-3745=1940-6029 ;
                      ISBN: 978-1-0716-4681-6=978-1-0716-4682-3 ;
                      doi:10.1007/978-1-0716-4682-3},
      booktitle     = {Organoids / Turksen, Kursad (Editor) ;
                       New York, NY : Springer US, 2025,
                       Chapter 574 ; ISSN: 1064-3745=1940-6029
                       ; ISBN:
                       978-1-0716-4681-6=978-1-0716-4682-3 ;
                       doi:10.1007/978-1-0716-4682-3},
      abstract     = {Many aspects of neurodegenerative disease pathology remain
                      unresolved. Why do certain neuronal subpopulations acquire
                      vulnerability to stress or mutations in ubiquitously
                      expressed genes, while others remain resilient? Do these
                      neurons harbor intrinsic marks that make them prone to
                      degeneration? Do these diseases have a neurodevelopmental
                      component? Lacking this fundamental knowledge hampers the
                      discovery of efficacious treatments. While it is well
                      established that human organoids enable the modeling of
                      brain-related diseases, we still lack an organoid model that
                      recapitulates the regionalization complexity and physiology
                      of the spinal cord. Here, we describe an advanced
                      experimental protocol to generate neuromuscular organoids
                      composed of a wide rostro-caudal (RC) diversity of spinal
                      motor neurons (spMNs) and mesodermal progenitor-derived
                      muscle cells. This model therefore allows for the robust and
                      reproducible study of neuromuscular unit development and
                      disease.},
      keywords     = {Organoids: cytology / Organoids: metabolism / Spinal Cord:
                      cytology / Spinal Cord: growth $\&$ development / Spinal
                      Cord: pathology / Humans / Motor Neurons: cytology / Motor
                      Neurons: metabolism / Animals / Mice / Neuromuscular
                      Junction / Human induced pluripotent stem cells (Other) /
                      Neuromesodermal progenitors (Other) / Neuromuscular spinal
                      cord organoids (Other) / Skeletal and smooth muscle (Other)
                      / Spinal motor neurons (Other)},
      cin          = {AG Rodriguez-Muela},
      ddc          = {570},
      cid          = {I:(DE-2719)1713001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)7},
      pubmed       = {pmid:39570548},
      doi          = {10.1007/7651_2024_574},
      url          = {https://pub.dzne.de/record/280243},
}