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000280244 1001_ $$00000-0002-4812-9458$$aSmejkalová, Barbora$$b0
000280244 245__ $$aDrebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice.
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000280244 520__ $$aSpinal cord injury (SCI) results in significant disruption of nerve fibers responsible for transmitting signals between the brain and body, often leading to partial or complete motor, sensory, and autonomic dysfunction below the injury site. Astrocytes are an important component in scar formation, crucial for suppression of injury propagation, effective wound healing, and the regulation of neuronal plasticity. Here, we identify the role of the actin-binding protein Drebrin (DBN) in reactive astrogliosis following SCI. SCI induces the upregulation of DBN in astrocytes, which controls immediate injury containment but also the long-term preservation of tissue integrity and healing in the spinal cord. DBN knockout results in enlarged spinal cord lesions, increased immune cell infiltration, and neurodegeneration. Mechanistically, DBN loss disrupts the polarization of scar border-forming astrocytes, leading to impaired encapsulation of the injury. In summary, DBN serves as a pivotal regulator of SCI outcome by modulating astrocytic polarity, which is essential for establishing a protective barrier confining the lesion site.
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000280244 650_7 $$2Other$$aimmune cell infiltration
000280244 650_7 $$2Other$$aneurodegeneration
000280244 650_7 $$2Other$$areactive astrogliosis
000280244 650_7 $$2Other$$aspinal cord injury
000280244 650_7 $$2NLM Chemicals$$adrebrins
000280244 650_7 $$2NLM Chemicals$$aNeuropeptides
000280244 650_2 $$2MeSH$$aAnimals
000280244 650_2 $$2MeSH$$aSpinal Cord Injuries: pathology
000280244 650_2 $$2MeSH$$aSpinal Cord Injuries: metabolism
000280244 650_2 $$2MeSH$$aAstrocytes: metabolism
000280244 650_2 $$2MeSH$$aAstrocytes: pathology
000280244 650_2 $$2MeSH$$aNeuropeptides: metabolism
000280244 650_2 $$2MeSH$$aNeuropeptides: genetics
000280244 650_2 $$2MeSH$$aUp-Regulation: physiology
000280244 650_2 $$2MeSH$$aRecovery of Function: physiology
000280244 650_2 $$2MeSH$$aCell Polarity: physiology
000280244 650_2 $$2MeSH$$aCell Polarity: genetics
000280244 650_2 $$2MeSH$$aMice
000280244 650_2 $$2MeSH$$aMice, Knockout
000280244 650_2 $$2MeSH$$aMice, Inbred C57BL
000280244 650_2 $$2MeSH$$aDisease Models, Animal
000280244 650_2 $$2MeSH$$aGliosis: pathology
000280244 650_2 $$2MeSH$$aGliosis: metabolism
000280244 650_2 $$2MeSH$$aFemale
000280244 650_2 $$2MeSH$$aSpinal Cord: pathology
000280244 650_2 $$2MeSH$$aSpinal Cord: metabolism
000280244 7001_ $$0P:(DE-2719)9001752$$aOrnaghi, Marta$$b1
000280244 7001_ $$00000-0003-2784-8434$$aŠtěpánková, Kateřina$$b2
000280244 7001_ $$0P:(DE-2719)9002206$$aSchiweck, Juliane$$b3$$udzne
000280244 7001_ $$00000-0001-7622-5837$$aMachová Urdzíková, Lucia$$b4
000280244 7001_ $$00000-0002-4602-8143$$aHuelse, Robert$$b5
000280244 7001_ $$00000-0002-5053-2211$$aMueller, Susanne$$b6
000280244 7001_ $$00000-0001-8777-4823$$aBoehm-Sturm, Philipp$$b7
000280244 7001_ $$00000-0002-9798-9083$$aKwok, Jessica C F$$b8
000280244 7001_ $$00000-0002-7990-4568$$aFawcett, James$$b9
000280244 7001_ $$00000-0002-6573-4529$$aMurk, Kai$$b10
000280244 7001_ $$00000-0001-7873-8687$$aEickholt, Britta J$$b11
000280244 7001_ $$aJendelová, Pavla$$b12
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