TY  - JOUR
AU  - Smejkalová, Barbora
AU  - Ornaghi, Marta
AU  - Štěpánková, Kateřina
AU  - Schiweck, Juliane
AU  - Machová Urdzíková, Lucia
AU  - Huelse, Robert
AU  - Mueller, Susanne
AU  - Boehm-Sturm, Philipp
AU  - Kwok, Jessica C F
AU  - Fawcett, James
AU  - Murk, Kai
AU  - Eickholt, Britta J
AU  - Jendelová, Pavla
TI  - Drebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice.
JO  - Glia
VL  - 73
IS  - 9
SN  - 0894-1491
CY  - Bognor Regis [u.a.]
PB  - Wiley-Liss
M1  - DZNE-2025-00922
SP  - 1910 - 1924
PY  - 2025
AB  - Spinal cord injury (SCI) results in significant disruption of nerve fibers responsible for transmitting signals between the brain and body, often leading to partial or complete motor, sensory, and autonomic dysfunction below the injury site. Astrocytes are an important component in scar formation, crucial for suppression of injury propagation, effective wound healing, and the regulation of neuronal plasticity. Here, we identify the role of the actin-binding protein Drebrin (DBN) in reactive astrogliosis following SCI. SCI induces the upregulation of DBN in astrocytes, which controls immediate injury containment but also the long-term preservation of tissue integrity and healing in the spinal cord. DBN knockout results in enlarged spinal cord lesions, increased immune cell infiltration, and neurodegeneration. Mechanistically, DBN loss disrupts the polarization of scar border-forming astrocytes, leading to impaired encapsulation of the injury. In summary, DBN serves as a pivotal regulator of SCI outcome by modulating astrocytic polarity, which is essential for establishing a protective barrier confining the lesion site.
KW  - Animals
KW  - Spinal Cord Injuries: pathology
KW  - Spinal Cord Injuries: metabolism
KW  - Astrocytes: metabolism
KW  - Astrocytes: pathology
KW  - Neuropeptides: metabolism
KW  - Neuropeptides: genetics
KW  - Up-Regulation: physiology
KW  - Recovery of Function: physiology
KW  - Cell Polarity: physiology
KW  - Cell Polarity: genetics
KW  - Mice
KW  - Mice, Knockout
KW  - Mice, Inbred C57BL
KW  - Disease Models, Animal
KW  - Gliosis: pathology
KW  - Gliosis: metabolism
KW  - Female
KW  - Spinal Cord: pathology
KW  - Spinal Cord: metabolism
KW  - immune cell infiltration (Other)
KW  - neurodegeneration (Other)
KW  - reactive astrogliosis (Other)
KW  - spinal cord injury (Other)
KW  - drebrins (NLM Chemicals)
KW  - Neuropeptides (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40497424
C2  - pmc:PMC12313004
DO  - DOI:10.1002/glia.70048
UR  - https://pub.dzne.de/record/280244
ER  -