Home > Publications Database > Drebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice. > print

001     280244
005     20250831001817.0
024 7 _ |a 10.1002/glia.70048
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100 1 _ |a Smejkalová, Barbora
|0 0000-0002-4812-9458
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245 _ _ |a Drebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice.
260 _ _ |a Bognor Regis [u.a.]
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520 _ _ |a Spinal cord injury (SCI) results in significant disruption of nerve fibers responsible for transmitting signals between the brain and body, often leading to partial or complete motor, sensory, and autonomic dysfunction below the injury site. Astrocytes are an important component in scar formation, crucial for suppression of injury propagation, effective wound healing, and the regulation of neuronal plasticity. Here, we identify the role of the actin-binding protein Drebrin (DBN) in reactive astrogliosis following SCI. SCI induces the upregulation of DBN in astrocytes, which controls immediate injury containment but also the long-term preservation of tissue integrity and healing in the spinal cord. DBN knockout results in enlarged spinal cord lesions, increased immune cell infiltration, and neurodegeneration. Mechanistically, DBN loss disrupts the polarization of scar border-forming astrocytes, leading to impaired encapsulation of the injury. In summary, DBN serves as a pivotal regulator of SCI outcome by modulating astrocytic polarity, which is essential for establishing a protective barrier confining the lesion site.
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650 _ 7 |a immune cell infiltration
|2 Other
650 _ 7 |a neurodegeneration
|2 Other
650 _ 7 |a reactive astrogliosis
|2 Other
650 _ 7 |a spinal cord injury
|2 Other
650 _ 7 |a drebrins
|2 NLM Chemicals
650 _ 7 |a Neuropeptides
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Spinal Cord Injuries: pathology
|2 MeSH
650 _ 2 |a Spinal Cord Injuries: metabolism
|2 MeSH
650 _ 2 |a Astrocytes: metabolism
|2 MeSH
650 _ 2 |a Astrocytes: pathology
|2 MeSH
650 _ 2 |a Neuropeptides: metabolism
|2 MeSH
650 _ 2 |a Neuropeptides: genetics
|2 MeSH
650 _ 2 |a Up-Regulation: physiology
|2 MeSH
650 _ 2 |a Recovery of Function: physiology
|2 MeSH
650 _ 2 |a Cell Polarity: physiology
|2 MeSH
650 _ 2 |a Cell Polarity: genetics
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Gliosis: pathology
|2 MeSH
650 _ 2 |a Gliosis: metabolism
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Spinal Cord: pathology
|2 MeSH
650 _ 2 |a Spinal Cord: metabolism
|2 MeSH
700 1 _ |a Ornaghi, Marta
|0 P:(DE-2719)9001752
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700 1 _ |a Štěpánková, Kateřina
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700 1 _ |a Schiweck, Juliane
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700 1 _ |a Machová Urdzíková, Lucia
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700 1 _ |a Huelse, Robert
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700 1 _ |a Mueller, Susanne
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700 1 _ |a Boehm-Sturm, Philipp
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700 1 _ |a Kwok, Jessica C F
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700 1 _ |a Fawcett, James
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700 1 _ |a Murk, Kai
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700 1 _ |a Eickholt, Britta J
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700 1 _ |a Jendelová, Pavla
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773 _ _ |a 10.1002/glia.70048
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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