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000280253 037__ $$aDZNE-2025-00931
000280253 041__ $$aEnglish
000280253 082__ $$a570
000280253 1001_ $$aRysop, Anna Uta$$b0
000280253 245__ $$aFeasibility of Home-Based Transcranial Direct Current Stimulation with Telerehabilitation in Primary Progressive Aphasia-A Case Series.
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000280253 520__ $$aBackground: Primary progressive aphasia (PPA) is a neurodegenerative disease characterised by progressive impairment of speech and language abilities. Intensive speech and language teletherapy combined with remotely supervised, self-administered transcranial direct current stimulation (tDCS) may be suited to remove barriers to accessing potentially effective treatments, but there is only limited evidence on the feasibility of this combined approach. Methods: This pilot case series investigated the feasibility, tolerability and preliminary efficacy of a novel telerehabilitation programme combined with home-based, self-administered tDCS for people with primary progressive aphasia (pwPPA). The intervention programme was co-developed with pwPPA and their caregivers, to reflect their priorities regarding treatment content and outcomes (i.e., naming, functional communication). Results: Two pwPPA successfully completed the telerehabilitation intervention with daily naming training and communicative-pragmatic therapy paired with tDCS, over 10 consecutive workdays. Caregivers assisted in the setup of equipment required for teletherapy and home-based tDCS. Participants successfully completed the programme with a 95% completion rate. Home-based tDCS was well tolerated. Both participants showed improvements in naming and communication, suggesting preliminary efficacy of the intervention. Conclusions: Overall, this study demonstrates the feasibility and potential benefit of a novel, easily accessible and patient-relevant telerehabilitation intervention for pwPPA, which requires confirmation in a future larger-scale exploratory trial.
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000280253 650_7 $$2Other$$afeasibility
000280253 650_7 $$2Other$$ahome-based transcranial direct current stimulation
000280253 650_7 $$2Other$$aprimary progressive aphasia
000280253 650_7 $$2Other$$asafety
000280253 650_7 $$2Other$$atelerehabilitation
000280253 650_7 $$2Other$$atolerability
000280253 7001_ $$00000-0002-3265-7176$$aGrewe, Tanja$$b1
000280253 7001_ $$aBreitenstein, Caterina$$b2
000280253 7001_ $$aBinkofski, Ferdinand$$b3
000280253 7001_ $$aRoheger, Mandy$$b4
000280253 7001_ $$aUnger, Nina$$b5
000280253 7001_ $$0P:(DE-2719)2812683$$aFlöel, Agnes$$b6$$udzne
000280253 7001_ $$aMeinzer, Marcus$$b7
000280253 770__ $$aPrimary Progressive Aphasia: What Happens to Speech and Language? What Can We Do to Help?
000280253 773__ $$0PERI:(DE-600)2651993-8$$a10.3390/brainsci15070742$$gVol. 15, no. 7, p. 742 -$$n7$$p742$$tBrain Sciences$$v15$$x2076-3425$$y2025
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