TY  - JOUR
AU  - Rysop, Anna Uta
AU  - Grewe, Tanja
AU  - Breitenstein, Caterina
AU  - Binkofski, Ferdinand
AU  - Roheger, Mandy
AU  - Unger, Nina
AU  - Flöel, Agnes
AU  - Meinzer, Marcus
TI  - Feasibility of Home-Based Transcranial Direct Current Stimulation with Telerehabilitation in Primary Progressive Aphasia-A Case Series.
JO  - Brain Sciences
VL  - 15
IS  - 7
SN  - 2076-3425
CY  - Basel
PB  - MDPI AG
M1  - DZNE-2025-00931
SP  - 742
PY  - 2025
AB  - Background: Primary progressive aphasia (PPA) is a neurodegenerative disease characterised by progressive impairment of speech and language abilities. Intensive speech and language teletherapy combined with remotely supervised, self-administered transcranial direct current stimulation (tDCS) may be suited to remove barriers to accessing potentially effective treatments, but there is only limited evidence on the feasibility of this combined approach. Methods: This pilot case series investigated the feasibility, tolerability and preliminary efficacy of a novel telerehabilitation programme combined with home-based, self-administered tDCS for people with primary progressive aphasia (pwPPA). The intervention programme was co-developed with pwPPA and their caregivers, to reflect their priorities regarding treatment content and outcomes (i.e., naming, functional communication). Results: Two pwPPA successfully completed the telerehabilitation intervention with daily naming training and communicative-pragmatic therapy paired with tDCS, over 10 consecutive workdays. Caregivers assisted in the setup of equipment required for teletherapy and home-based tDCS. Participants successfully completed the programme with a 95
KW  - feasibility (Other)
KW  - home-based transcranial direct current stimulation (Other)
KW  - primary progressive aphasia (Other)
KW  - safety (Other)
KW  - telerehabilitation (Other)
KW  - tolerability (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40722333
C2  - pmc:PMC12293336
DO  - DOI:10.3390/brainsci15070742
UR  - https://pub.dzne.de/record/280253
ER  -