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@ARTICLE{Rysop:280253,
      author       = {Rysop, Anna Uta and Grewe, Tanja and Breitenstein, Caterina
                      and Binkofski, Ferdinand and Roheger, Mandy and Unger, Nina
                      and Flöel, Agnes and Meinzer, Marcus},
      title        = {{F}easibility of {H}ome-{B}ased {T}ranscranial {D}irect
                      {C}urrent {S}timulation with {T}elerehabilitation in
                      {P}rimary {P}rogressive {A}phasia-{A} {C}ase {S}eries.},
      journal      = {Brain Sciences},
      volume       = {15},
      number       = {7},
      issn         = {2076-3425},
      address      = {Basel},
      publisher    = {MDPI AG},
      reportid     = {DZNE-2025-00931},
      pages        = {742},
      year         = {2025},
      abstract     = {Background: Primary progressive aphasia (PPA) is a
                      neurodegenerative disease characterised by progressive
                      impairment of speech and language abilities. Intensive
                      speech and language teletherapy combined with remotely
                      supervised, self-administered transcranial direct current
                      stimulation (tDCS) may be suited to remove barriers to
                      accessing potentially effective treatments, but there is
                      only limited evidence on the feasibility of this combined
                      approach. Methods: This pilot case series investigated the
                      feasibility, tolerability and preliminary efficacy of a
                      novel telerehabilitation programme combined with home-based,
                      self-administered tDCS for people with primary progressive
                      aphasia (pwPPA). The intervention programme was co-developed
                      with pwPPA and their caregivers, to reflect their priorities
                      regarding treatment content and outcomes (i.e., naming,
                      functional communication). Results: Two pwPPA successfully
                      completed the telerehabilitation intervention with daily
                      naming training and communicative-pragmatic therapy paired
                      with tDCS, over 10 consecutive workdays. Caregivers assisted
                      in the setup of equipment required for teletherapy and
                      home-based tDCS. Participants successfully completed the
                      programme with a $95\%$ completion rate. Home-based tDCS was
                      well tolerated. Both participants showed improvements in
                      naming and communication, suggesting preliminary efficacy of
                      the intervention. Conclusions: Overall, this study
                      demonstrates the feasibility and potential benefit of a
                      novel, easily accessible and patient-relevant
                      telerehabilitation intervention for pwPPA, which requires
                      confirmation in a future larger-scale exploratory trial.},
      keywords     = {feasibility (Other) / home-based transcranial direct
                      current stimulation (Other) / primary progressive aphasia
                      (Other) / safety (Other) / telerehabilitation (Other) /
                      tolerability (Other)},
      cin          = {AG Flöel},
      ddc          = {570},
      cid          = {I:(DE-2719)5000081},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40722333},
      pmc          = {pmc:PMC12293336},
      doi          = {10.3390/brainsci15070742},
      url          = {https://pub.dzne.de/record/280253},
}