%0 Journal Article
%A Wicherski, Julia
%A Peltner, Jonas
%A Becker, Cornelia
%A Schüssel, Katrin
%A Brückner, Gabriela
%A Schlotmann, Andreas
%A Schröder, Helmut
%A Kern, Winfried V
%A Haenisch, Britta
%T Association between fluoroquinolones and retinal detachment: insights from a large German health claims-based cohort study.
%J BMC ophthalmology
%V 25
%N 1
%@ 1471-2415
%C London
%I BioMed Central
%M DZNE-2025-00936
%P 447
%D 2025
%X Real-world evidence on fluoroquinolone-associated retinal detachment is contradictory. Therefore, we aim to examine the association between newly prescribed fluoroquinolones and the occurrence of retinal detachment with recent data from a large central European country.A cohort study with an active comparator new user design was conducted. Dispensings of fluoroquinolone episodes were compared to a group of reference antibiotic episodes (amoxicillin, amoxicillin clavulanic acid, azithromycin, cefuroxime, cephalexin, clindamycin, sulfamethoxazole-trimethoprim, and doxycycline). Data from one of the largest statutory health insurances in Germany, the AOK, were used to follow up individuals with new antibiotic dispensing during the years 2014-2018 for the occurrence of retinal detachment. Piece-wise exponential additive mixed models adjusted for person-time, age, gender, comorbidities, year, and quarter at index were applied to estimate adjusted hazard ratios (aHR) with corresponding 95
%K Humans
%K Fluoroquinolones: adverse effects
%K Germany: epidemiology
%K Female
%K Male
%K Retinal Detachment: epidemiology
%K Retinal Detachment: chemically induced
%K Middle Aged
%K Anti-Bacterial Agents: adverse effects
%K Aged
%K Adult
%K Incidence
%K Cohort Studies
%K Retrospective Studies
%K Follow-Up Studies
%K Young Adult
%K Active comparator new user design (Other)
%K Administrative cohort (Other)
%K Adverse drug reactions (Other)
%K Fluoroquinolones (Other)
%K Real-world data (Other)
%K Fluoroquinolones (NLM Chemicals)
%K Anti-Bacterial Agents (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40775308
%R 10.1186/s12886-025-04284-5
%U https://pub.dzne.de/record/280258