TY  - JOUR
AU  - Wicherski, Julia
AU  - Peltner, Jonas
AU  - Becker, Cornelia
AU  - Schüssel, Katrin
AU  - Brückner, Gabriela
AU  - Schlotmann, Andreas
AU  - Schröder, Helmut
AU  - Kern, Winfried V
AU  - Haenisch, Britta
TI  - Association between fluoroquinolones and retinal detachment: insights from a large German health claims-based cohort study.
JO  - BMC ophthalmology
VL  - 25
IS  - 1
SN  - 1471-2415
CY  - London
PB  - BioMed Central
M1  - DZNE-2025-00936
SP  - 447
PY  - 2025
AB  - Real-world evidence on fluoroquinolone-associated retinal detachment is contradictory. Therefore, we aim to examine the association between newly prescribed fluoroquinolones and the occurrence of retinal detachment with recent data from a large central European country.A cohort study with an active comparator new user design was conducted. Dispensings of fluoroquinolone episodes were compared to a group of reference antibiotic episodes (amoxicillin, amoxicillin clavulanic acid, azithromycin, cefuroxime, cephalexin, clindamycin, sulfamethoxazole-trimethoprim, and doxycycline). Data from one of the largest statutory health insurances in Germany, the AOK, were used to follow up individuals with new antibiotic dispensing during the years 2014-2018 for the occurrence of retinal detachment. Piece-wise exponential additive mixed models adjusted for person-time, age, gender, comorbidities, year, and quarter at index were applied to estimate adjusted hazard ratios (aHR) with corresponding 95
KW  - Humans
KW  - Fluoroquinolones: adverse effects
KW  - Germany: epidemiology
KW  - Female
KW  - Male
KW  - Retinal Detachment: epidemiology
KW  - Retinal Detachment: chemically induced
KW  - Middle Aged
KW  - Anti-Bacterial Agents: adverse effects
KW  - Aged
KW  - Adult
KW  - Incidence
KW  - Cohort Studies
KW  - Retrospective Studies
KW  - Follow-Up Studies
KW  - Young Adult
KW  - Active comparator new user design (Other)
KW  - Administrative cohort (Other)
KW  - Adverse drug reactions (Other)
KW  - Fluoroquinolones (Other)
KW  - Real-world data (Other)
KW  - Fluoroquinolones (NLM Chemicals)
KW  - Anti-Bacterial Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40775308
DO  - DOI:10.1186/s12886-025-04284-5
UR  - https://pub.dzne.de/record/280258
ER  -