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@ARTICLE{Wicherski:280258,
      author       = {Wicherski, Julia and Peltner, Jonas and Becker, Cornelia
                      and Schüssel, Katrin and Brückner, Gabriela and
                      Schlotmann, Andreas and Schröder, Helmut and Kern, Winfried
                      V and Haenisch, Britta},
      title        = {{A}ssociation between fluoroquinolones and retinal
                      detachment: insights from a large {G}erman health
                      claims-based cohort study.},
      journal      = {BMC ophthalmology},
      volume       = {25},
      number       = {1},
      issn         = {1471-2415},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2025-00936},
      pages        = {447},
      year         = {2025},
      abstract     = {Real-world evidence on fluoroquinolone-associated retinal
                      detachment is contradictory. Therefore, we aim to examine
                      the association between newly prescribed fluoroquinolones
                      and the occurrence of retinal detachment with recent data
                      from a large central European country.A cohort study with an
                      active comparator new user design was conducted. Dispensings
                      of fluoroquinolone episodes were compared to a group of
                      reference antibiotic episodes (amoxicillin, amoxicillin
                      clavulanic acid, azithromycin, cefuroxime, cephalexin,
                      clindamycin, sulfamethoxazole-trimethoprim, and
                      doxycycline). Data from one of the largest statutory health
                      insurances in Germany, the AOK, were used to follow up
                      individuals with new antibiotic dispensing during the years
                      2014-2018 for the occurrence of retinal detachment.
                      Piece-wise exponential additive mixed models adjusted for
                      person-time, age, gender, comorbidities, year, and quarter
                      at index were applied to estimate adjusted hazard ratios
                      (aHR) with corresponding $95\%$ confidence intervals $(95\%$
                      CI).In total, 15,232,585 antibiotic episodes were included
                      in the cohort of which $0.05\%$ episodes had an incident
                      retinal detachment. The covariate-adjusted hazard ratio for
                      fluoroquinolone episodes was 1.01 [0.95;1.08]. Likewise, in
                      the propensity score-matched cohort the covariate-adjusted
                      hazard ratio was 0.99 [0.92;1.07]. Moreover, there was
                      little evidence for differences in age and gender subgroups,
                      by follow-up time, selection of active comparator agent,
                      dosage category, or censoring approach.This large German
                      cohort study found no meaningful real-world evidence for the
                      association between fluoroquinolones and retinal detachment
                      compared to a group of active comparator antibiotics.},
      keywords     = {Humans / Fluoroquinolones: adverse effects / Germany:
                      epidemiology / Female / Male / Retinal Detachment:
                      epidemiology / Retinal Detachment: chemically induced /
                      Middle Aged / Anti-Bacterial Agents: adverse effects / Aged
                      / Adult / Incidence / Cohort Studies / Retrospective Studies
                      / Follow-Up Studies / Young Adult / Active comparator new
                      user design (Other) / Administrative cohort (Other) /
                      Adverse drug reactions (Other) / Fluoroquinolones (Other) /
                      Real-world data (Other) / Fluoroquinolones (NLM Chemicals) /
                      Anti-Bacterial Agents (NLM Chemicals)},
      cin          = {AG Hänisch},
      ddc          = {610},
      cid          = {I:(DE-2719)1013010},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40775308},
      doi          = {10.1186/s12886-025-04284-5},
      url          = {https://pub.dzne.de/record/280258},
}