TY  - JOUR
AU  - Lohner, Valerie
AU  - Badhwar, Amanpreet
AU  - Detcheverry, Flavie E
AU  - García, Cindy L
AU  - Gellersen, Helena M
AU  - Khodakarami, Zahra
AU  - Lattmann, Rene
AU  - Li, Rui
AU  - Low, Audrey
AU  - Mazo, Claudia
AU  - Metz, Amelie
AU  - Parent, Olivier
AU  - Phillips, Veronica
AU  - Saeed, Usman
AU  - Tan, Sean Y W
AU  - Tamburin, Stefano
AU  - Llewellyn, David J
AU  - Rittman, Timothy
AU  - Waters, Sheena
AU  - Bernal, Jose
TI  - Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis.
JO  - Alzheimer's research & therapy
VL  - 17
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DZNE-2025-00937
SP  - 183
PY  - 2025
AB  - Background:Cerebral small vessel disease (CSVD) is a common neurological condition that contributes to strokes, dementia, disability, and mortality worldwide. We conducted a systematic review and meta-analysis to investigate the use of neuroimaging CSVD markers in machine learning (ML) based diagnosis and prognosis of cognitive impairment and dementia, and identify both methodological changes over time and barriers to clinical translation.Methods:Following the PRISMA guidelines, we systematically searched for original studies that used both neuroimaging CSVD markers and ML methods for diagnosing and prognosing neurodegenerative diseases (preregistration in PROSPERO: CRD42022366767). Each paper was independently reviewed by a pair of reviewers at all stages, with a third consulted to resolve conflicts. We meta-analysed the effectiveness of ML models to distinguish healthy controls from Alzheimer’s dementia and cognitive impairment, using area under the curve (AUC) as the performance metric.Results:We identified 75 studies: 43 on diagnosis, 27 on prognosis, and 5 on both. Nearly 60
KW  - Alzheimer’s dementia (Other)
KW  - Artificial intelligence (Other)
KW  - Cerebral small vessel disease (Other)
KW  - Cognitive impairment (Other)
KW  - Dementia (Other)
KW  - Machine learning (Other)
KW  - Neurodegenerative diseases (Other)
KW  - Neuroimaging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40775365
DO  - DOI:10.1186/s13195-025-01815-6
UR  - https://pub.dzne.de/record/280259
ER  -