TY  - JOUR
AU  - Ye, Lan
AU  - Greten, Stephan
AU  - Wilkens, Ida
AU  - Wegner, Florian
AU  - Krey, Lea
AU  - Höllerhage, Matthias
AU  - Pötter-Nerger, Monika
AU  - Zeitzschel, Molly
AU  - Hagena, Keno
AU  - Kassubek, Jan
AU  - Süß, Patrick
AU  - Winkler, Jürgen
AU  - Berg, Daniela
AU  - Paschen, Steffen
AU  - Tönges, Lars
AU  - Gruber, Doreen
AU  - Gandor, Florin
AU  - Jost, Wolfgang H
AU  - Kühn, Andrea A
AU  - Claus, Inga
AU  - Warnecke, Tobias
AU  - Pedrosa, David J
AU  - Eggers, Carsten
AU  - Trenkwalder, Claudia
AU  - Classen, Joseph
AU  - Schwarz, Johannes
AU  - Schnitzler, Alfons
AU  - Höglinger, Günter
AU  - Klietz, Martin
TI  - Tackling gender in progressive supranuclear palsy: Male patients present more apathy.
JO  - Journal of Parkinson's Disease
VL  - 15
IS  - 5
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2025-00942
SP  - 1024 - 1028
PY  - 2025
AB  - Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients.
KW  - Humans
KW  - Supranuclear Palsy, Progressive: physiopathology
KW  - Supranuclear Palsy, Progressive: psychology
KW  - Supranuclear Palsy, Progressive: complications
KW  - Male
KW  - Apathy: physiology
KW  - Female
KW  - Aged
KW  - Retrospective Studies
KW  - Middle Aged
KW  - Sex Factors
KW  - Severity of Illness Index
KW  - Germany
KW  - Aged, 80 and over
KW  - Depression: etiology
KW  - apathy (Other)
KW  - gender (Other)
KW  - progressive supranuclear palsy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40462618
DO  - DOI:10.1177/1877718X251343094
UR  - https://pub.dzne.de/record/280287
ER  -