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@ARTICLE{Rei:280288,
      author       = {Reiß, Julian and Ghosh, Sujal and Scheid, Michael and
                      Graafen, Lea and Scherenschlich, Nadine and Weinhold, Sandra
                      and Raba, Katharina and Paulusch, Stefan and De Dominico,
                      Elena and Pham, Thi X U and Beyer, Marc and Laws,
                      Hans-Jürgen and Niehues, Tim and Borkhardt, Arndt and
                      Uhrberg, Markus and Bennstein, Sabrina B},
      title        = {{A} human {NK} cell progenitor that originates in the
                      thymus and generates {KIR}+{NKG}2{A}- {NK} cells.},
      journal      = {Science advances},
      volume       = {11},
      number       = {32},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DZNE-2025-00943},
      pages        = {eadv9650},
      year         = {2025},
      abstract     = {KIR+NKG2A- natural killer (NK) cells have the unique
                      ability to detect down-regulation of single HLA-I allotypes,
                      frequently occurring in malignantly transformed and
                      virus-infected cells. We have recently shown that
                      circulating innate lymphoid cells 1 (cILC1s) have the
                      potential to generate such KIR+NKG2A- NK cells, but their
                      developmental origin was unknown. Here, we demonstrate that
                      the development of cILC1 is thymus dependent and identify a
                      putative progenitor of cILC1s in the thymus (thyILC1).
                      Single-cell RNA sequencing analysis revealed a close
                      relationship of thyILC1s to CD34+ double-negative
                      thymocytes. Both generated comparable NK cell frequencies,
                      while only thyILC1s could be efficiently differentiated into
                      KIR+NKG2A- NK cells. Last, patients with FOXN1
                      haploinsufficiency, showing congenital thymic hypoplasia,
                      exhibited a profound deficiency of cILC1s but not cILC2s and
                      cILC3s, demonstrating their specific thymus dependency.
                      Together, the data suggest that thyILC1s are the source of a
                      thymus-dependent NK cell differentiation pathway that
                      promotes generation of KIR+NKG2A- NK cells.},
      keywords     = {Humans / Killer Cells, Natural: metabolism / Killer Cells,
                      Natural: cytology / Killer Cells, Natural: immunology /
                      Thymus Gland: cytology / Thymus Gland: immunology / Thymus
                      Gland: metabolism / NK Cell Lectin-Like Receptor Subfamily
                      C: metabolism / Cell Differentiation / Receptors, KIR:
                      metabolism / NK Cell Lectin-Like Receptor Subfamily C (NLM
                      Chemicals) / Receptors, KIR (NLM Chemicals) / KLRC1 protein,
                      human (NLM Chemicals)},
      cin          = {AG Schultze / PRECISE / AG Beyer},
      ddc          = {500},
      cid          = {I:(DE-2719)1013038 / I:(DE-2719)1013031 /
                      I:(DE-2719)1013035},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 352
                      - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-352 /
                      G:(DE-HGF)POF4-351},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40779632},
      pmc          = {pmc:PMC12333686},
      doi          = {10.1126/sciadv.adv9650},
      url          = {https://pub.dzne.de/record/280288},
}