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000280292 1001_ $$00000-0001-7187-2664$$aSolomon, Pierre$$b0
000280292 245__ $$aIntegrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders.
000280292 260__ $$a[London]$$bSpringer Nature$$c2025
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000280292 520__ $$aMicro RNAs (miRNAs) play a crucial role as regulators of various biological processes and have been implicated in the pathogenesis of mental disorders such as schizophrenia and bipolar disorders. In this study, we investigate the expression patterns of miRNAs in the PsyCourse Study (n = 1786), contrasting three broad diagnostic groups: Psychotic (Schizophrenia-spectrum disorders), Affective (Bipolar Disorder I, II and recurrent Depression), and neurotypic healthy individuals. Through comprehensive analyses, including differential miRNA expression, miRNA transcriptome-wide association study (TWAS), and predictive modelling, we identified multiple miRNAs unique to Psychotic and Affective groups as well as shared by both. Furthermore, we performed integrative analysis to identify the target genes of the dysregulated miRNAs and elucidate their potential roles in psychosis. Our findings reveal significant alterations of multiple miRNAs such as miR-584-3p and miR-99b-5p across the studied diagnostic groups, highlighting their role as molecular correlates. Additionally, the miRNA TWAS analysis discovered previously known and novel genetically dysregulated miRNAs confirming the relevance in the etiology of the diagnostic groups. Importantly, novel factors and putative molecular mechanisms underlying these groups were uncovered through the integration of miRNA-target gene interactions. This comprehensive investigation provides valuable insights into the molecular underpinnings of severe mental disorders, shedding light on the complex regulatory networks involving miRNAs.
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000280292 650_7 $$2NLM Chemicals$$aMicroRNAs
000280292 650_2 $$2MeSH$$aHumans
000280292 650_2 $$2MeSH$$aMicroRNAs: genetics
000280292 650_2 $$2MeSH$$aMicroRNAs: metabolism
000280292 650_2 $$2MeSH$$aBipolar Disorder: genetics
000280292 650_2 $$2MeSH$$aMale
000280292 650_2 $$2MeSH$$aFemale
000280292 650_2 $$2MeSH$$aSchizophrenia: genetics
000280292 650_2 $$2MeSH$$aSchizophrenia: metabolism
000280292 650_2 $$2MeSH$$aMental Disorders: genetics
000280292 650_2 $$2MeSH$$aGene Expression Profiling: methods
000280292 650_2 $$2MeSH$$aAdult
000280292 650_2 $$2MeSH$$aTranscriptome: genetics
000280292 650_2 $$2MeSH$$aPsychotic Disorders: genetics
000280292 650_2 $$2MeSH$$aGene Regulatory Networks: genetics
000280292 650_2 $$2MeSH$$aGenome-Wide Association Study: methods
000280292 650_2 $$2MeSH$$aMiddle Aged
000280292 7001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b1$$eFirst author
000280292 7001_ $$aBudde, Monika$$b2
000280292 7001_ $$aGuiné, Jean-Baptiste$$b3
000280292 7001_ $$0P:(DE-2719)2812548$$aKrüger, Dennis Manfred$$b4
000280292 7001_ $$00000-0003-1774-0286$$aRiquin, Kevin$$b5
000280292 7001_ $$0P:(DE-2719)2811063$$aPena, Tonatiuh$$b6
000280292 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b7$$udzne
000280292 7001_ $$00000-0002-3330-7530$$aFourgeux, Cynthia$$b8
000280292 7001_ $$aAdorjan, Kristina$$b9
000280292 7001_ $$aHeilbronner, Maria$$b10
000280292 7001_ $$aKalman, Janos L$$b11
000280292 7001_ $$00000-0002-1357-2636$$aKohshour, Mojtaba Oraki$$b12
000280292 7001_ $$00000-0001-9366-8728$$aPapiol, Sergi$$b13
000280292 7001_ $$aReich-Erkelenz, Daniela$$b14
000280292 7001_ $$aSchaupp, Sabrina K$$b15
000280292 7001_ $$00000-0003-3105-5672$$aSchulte, Eva C$$b16
000280292 7001_ $$aSenner, Fanny$$b17
000280292 7001_ $$aVogl, Thomas$$b18
000280292 7001_ $$aAnghelescu, Ion-George$$b19
000280292 7001_ $$00000-0002-2445-9778$$aArolt, Volker$$b20
000280292 7001_ $$aBaune, Bernhardt T$$b21
000280292 7001_ $$00000-0002-0623-3759$$aDannlowski, Udo$$b22
000280292 7001_ $$aDietrich, Detlef E$$b23
000280292 7001_ $$0P:(DE-2719)2811701$$aFallgatter, Andreas$$b24$$udzne
000280292 7001_ $$aFigge, Christian$$b25
000280292 7001_ $$aJuckel, Georg$$b26
000280292 7001_ $$aKonrad, Carsten$$b27
000280292 7001_ $$00009-0007-5406-5319$$aReimer, Jens$$b28
000280292 7001_ $$00000-0001-5964-4087$$aReininghaus, Eva Z$$b29
000280292 7001_ $$aSchmauß, Max$$b30
000280292 7001_ $$aSpitzer, Carsten$$b31
000280292 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b32
000280292 7001_ $$aZimmermann, Jörg$$b33
000280292 7001_ $$0P:(DE-2719)2810585$$aSchütz, Anna-Lena$$b34$$udzne
000280292 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b35$$udzne
000280292 7001_ $$aSauvaget, Anne$$b36
000280292 7001_ $$0P:(DE-2719)2811040$$aFalkai, Peter$$b37
000280292 7001_ $$00000-0001-6624-2975$$aSchulze, Thomas G$$b38
000280292 7001_ $$0P:(DE-2719)2000047$$aFischer, André$$b39$$eLast author$$udzne
000280292 7001_ $$0P:(DE-2719)9000977$$aHeilbronner, Urs$$b40
000280292 7001_ $$00000-0002-9613-5297$$aPoschmann, Jeremie$$b41
000280292 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-025-03018-9$$gVol. 30, no. 9, p. 4364 - 4383$$n9$$p4364 - 4383$$tMolecular psychiatry$$v30$$x1359-4184$$y2025
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