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@ARTICLE{Solomon:280292,
      author       = {Solomon, Pierre and Kaurani, Lalit and Budde, Monika and
                      Guiné, Jean-Baptiste and Krüger, Dennis Manfred and
                      Riquin, Kevin and Pena, Tonatiuh and Burkhardt, Susanne and
                      Fourgeux, Cynthia and Adorjan, Kristina and Heilbronner,
                      Maria and Kalman, Janos L and Kohshour, Mojtaba Oraki and
                      Papiol, Sergi and Reich-Erkelenz, Daniela and Schaupp,
                      Sabrina K and Schulte, Eva C and Senner, Fanny and Vogl,
                      Thomas and Anghelescu, Ion-George and Arolt, Volker and
                      Baune, Bernhardt T and Dannlowski, Udo and Dietrich, Detlef
                      E and Fallgatter, Andreas and Figge, Christian and Juckel,
                      Georg and Konrad, Carsten and Reimer, Jens and Reininghaus,
                      Eva Z and Schmauß, Max and Spitzer, Carsten and Wiltfang,
                      Jens and Zimmermann, Jörg and Schütz, Anna-Lena and
                      Sananbenesi, Farahnaz and Sauvaget, Anne and Falkai, Peter
                      and Schulze, Thomas G and Fischer, André and Heilbronner,
                      Urs and Poschmann, Jeremie},
      title        = {{I}ntegrative analysis of mi{RNA} expression profiles
                      reveals distinct and common molecular mechanisms underlying
                      broad diagnostic groups of severe mental disorders.},
      journal      = {Molecular psychiatry},
      volume       = {30},
      number       = {9},
      issn         = {1359-4184},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00947},
      pages        = {4364 - 4383},
      year         = {2025},
      abstract     = {Micro RNAs (miRNAs) play a crucial role as regulators of
                      various biological processes and have been implicated in the
                      pathogenesis of mental disorders such as schizophrenia and
                      bipolar disorders. In this study, we investigate the
                      expression patterns of miRNAs in the PsyCourse Study (n =
                      1786), contrasting three broad diagnostic groups: Psychotic
                      (Schizophrenia-spectrum disorders), Affective (Bipolar
                      Disorder I, II and recurrent Depression), and neurotypic
                      healthy individuals. Through comprehensive analyses,
                      including differential miRNA expression, miRNA
                      transcriptome-wide association study (TWAS), and predictive
                      modelling, we identified multiple miRNAs unique to Psychotic
                      and Affective groups as well as shared by both. Furthermore,
                      we performed integrative analysis to identify the target
                      genes of the dysregulated miRNAs and elucidate their
                      potential roles in psychosis. Our findings reveal
                      significant alterations of multiple miRNAs such as
                      miR-584-3p and miR-99b-5p across the studied diagnostic
                      groups, highlighting their role as molecular correlates.
                      Additionally, the miRNA TWAS analysis discovered previously
                      known and novel genetically dysregulated miRNAs confirming
                      the relevance in the etiology of the diagnostic groups.
                      Importantly, novel factors and putative molecular mechanisms
                      underlying these groups were uncovered through the
                      integration of miRNA-target gene interactions. This
                      comprehensive investigation provides valuable insights into
                      the molecular underpinnings of severe mental disorders,
                      shedding light on the complex regulatory networks involving
                      miRNAs.},
      keywords     = {Humans / MicroRNAs: genetics / MicroRNAs: metabolism /
                      Bipolar Disorder: genetics / Male / Female / Schizophrenia:
                      genetics / Schizophrenia: metabolism / Mental Disorders:
                      genetics / Gene Expression Profiling: methods / Adult /
                      Transcriptome: genetics / Psychotic Disorders: genetics /
                      Gene Regulatory Networks: genetics / Genome-Wide Association
                      Study: methods / Middle Aged / MicroRNAs (NLM Chemicals)},
      cin          = {AG Fischer / AG Wiltfang / Bioinformatics Unit (Göttingen)
                      / AG Sananbenesi},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1410006 /
                      I:(DE-2719)1440016 / I:(DE-2719)1410004},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353) / 899 - ohne Topic
                      (POF4-899)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353 /
                      G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40263528},
      doi          = {10.1038/s41380-025-03018-9},
      url          = {https://pub.dzne.de/record/280292},
}