Home > Publications Database > Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders. > print

001     280292
005     20250907001846.0
024 7 _ |a 10.1038/s41380-025-03018-9
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024 7 _ |a pmid:40263528
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024 7 _ |a 1359-4184
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024 7 _ |a 1476-5578
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037 _ _ |a DZNE-2025-00947
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Solomon, Pierre
|0 0000-0001-7187-2664
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245 _ _ |a Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders.
260 _ _ |a [London]
|c 2025
|b Springer Nature
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520 _ _ |a Micro RNAs (miRNAs) play a crucial role as regulators of various biological processes and have been implicated in the pathogenesis of mental disorders such as schizophrenia and bipolar disorders. In this study, we investigate the expression patterns of miRNAs in the PsyCourse Study (n = 1786), contrasting three broad diagnostic groups: Psychotic (Schizophrenia-spectrum disorders), Affective (Bipolar Disorder I, II and recurrent Depression), and neurotypic healthy individuals. Through comprehensive analyses, including differential miRNA expression, miRNA transcriptome-wide association study (TWAS), and predictive modelling, we identified multiple miRNAs unique to Psychotic and Affective groups as well as shared by both. Furthermore, we performed integrative analysis to identify the target genes of the dysregulated miRNAs and elucidate their potential roles in psychosis. Our findings reveal significant alterations of multiple miRNAs such as miR-584-3p and miR-99b-5p across the studied diagnostic groups, highlighting their role as molecular correlates. Additionally, the miRNA TWAS analysis discovered previously known and novel genetically dysregulated miRNAs confirming the relevance in the etiology of the diagnostic groups. Importantly, novel factors and putative molecular mechanisms underlying these groups were uncovered through the integration of miRNA-target gene interactions. This comprehensive investigation provides valuable insights into the molecular underpinnings of severe mental disorders, shedding light on the complex regulatory networks involving miRNAs.
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a MicroRNAs
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a MicroRNAs: genetics
|2 MeSH
650 _ 2 |a MicroRNAs: metabolism
|2 MeSH
650 _ 2 |a Bipolar Disorder: genetics
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Schizophrenia: genetics
|2 MeSH
650 _ 2 |a Schizophrenia: metabolism
|2 MeSH
650 _ 2 |a Mental Disorders: genetics
|2 MeSH
650 _ 2 |a Gene Expression Profiling: methods
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Transcriptome: genetics
|2 MeSH
650 _ 2 |a Psychotic Disorders: genetics
|2 MeSH
650 _ 2 |a Gene Regulatory Networks: genetics
|2 MeSH
650 _ 2 |a Genome-Wide Association Study: methods
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
700 1 _ |a Kaurani, Lalit
|0 P:(DE-2719)2812832
|b 1
|e First author
700 1 _ |a Budde, Monika
|b 2
700 1 _ |a Guiné, Jean-Baptiste
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700 1 _ |a Krüger, Dennis Manfred
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700 1 _ |a Riquin, Kevin
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700 1 _ |a Pena, Tonatiuh
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700 1 _ |a Burkhardt, Susanne
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700 1 _ |a Fourgeux, Cynthia
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700 1 _ |a Adorjan, Kristina
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700 1 _ |a Heilbronner, Maria
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700 1 _ |a Kalman, Janos L
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700 1 _ |a Kohshour, Mojtaba Oraki
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700 1 _ |a Papiol, Sergi
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700 1 _ |a Reich-Erkelenz, Daniela
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700 1 _ |a Schaupp, Sabrina K
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700 1 _ |a Schulte, Eva C
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700 1 _ |a Senner, Fanny
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700 1 _ |a Vogl, Thomas
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700 1 _ |a Anghelescu, Ion-George
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700 1 _ |a Arolt, Volker
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700 1 _ |a Baune, Bernhardt T
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700 1 _ |a Dannlowski, Udo
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700 1 _ |a Dietrich, Detlef E
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700 1 _ |a Fallgatter, Andreas
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700 1 _ |a Figge, Christian
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700 1 _ |a Juckel, Georg
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700 1 _ |a Konrad, Carsten
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700 1 _ |a Reimer, Jens
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700 1 _ |a Reininghaus, Eva Z
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700 1 _ |a Schmauß, Max
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700 1 _ |a Spitzer, Carsten
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700 1 _ |a Wiltfang, Jens
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700 1 _ |a Zimmermann, Jörg
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700 1 _ |a Schütz, Anna-Lena
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700 1 _ |a Sananbenesi, Farahnaz
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700 1 _ |a Sauvaget, Anne
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700 1 _ |a Falkai, Peter
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700 1 _ |a Schulze, Thomas G
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700 1 _ |a Fischer, André
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700 1 _ |a Heilbronner, Urs
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700 1 _ |a Poschmann, Jeremie
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773 _ _ |a 10.1038/s41380-025-03018-9
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