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@ARTICLE{Muqaku:280293,
      author       = {Muqaku, Besnik and Dorst, Johannes and Wiesenfarth,
                      Maximilian and Otto, Markus and Ludolph, Albert C and Oeckl,
                      Patrick},
      title        = {{P}eptidomic analysis of {CSF} reveals new biomarker
                      candidates for amyotrophic lateral sclerosis.},
      journal      = {EMBO molecular medicine},
      volume       = {17},
      number       = {8},
      issn         = {1757-4676},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2025-00948},
      pages        = {1926 - 1949},
      year         = {2025},
      abstract     = {Amyotrophic lateral sclerosis (ALS) is a devastating
                      neurodegenerative disease, and novel biomarkers are needed.
                      We applied mass-spectrometry-based peptidomic analysis in
                      cerebrospinal fluid (CSF) samples of ALS and
                      non-neurodegenerative control patients (Con) from a
                      discovery (n = 48) and validation (n = 109) cohort for
                      biomarker discovery. Systematic selection revealed a panel
                      of eight novel peptide biomarker candidates for ALS (out of
                      33,605) derived from seven proteins. In the validation
                      cohort, NFL, MAP1B, MYL1, and APOC1 peptides were
                      upregulated, and peptides from CADM3, SCG1, and PENK were
                      downregulated in ALS compared to Con. The peptides (except
                      NFL) were not changed in other neurodegenerative diseases,
                      including Alzheimer´s disease, frontotemporal dementia and
                      Parkinson´s disease. Combination of all peptides in a
                      logistic regression model led to an area under the curve
                      value of $98\%$ for the discrimination of ALS from controls.
                      Data of the NFL peptide strongly correlated with an
                      established NFL immunoassay (Ella, r = 0.97). The peptide
                      biomarker candidates are derived from proteins with
                      different function, and their determination with our method
                      provides the opportunity for simultaneous investigation of
                      key processes in ALS.},
      keywords     = {Humans / Amyotrophic Lateral Sclerosis: diagnosis /
                      Amyotrophic Lateral Sclerosis: cerebrospinal fluid /
                      Amyotrophic Lateral Sclerosis: pathology / Biomarkers:
                      cerebrospinal fluid / Female / Male / Middle Aged / Aged /
                      Peptides: cerebrospinal fluid / Cohort Studies / Mass
                      Spectrometry / Proteomics: methods / Adult / ALS (Other) /
                      Biomarker (Other) / Muscle (Other) / Neurodegeneration
                      (Other) / Peptidomics (Other) / Biomarkers (NLM Chemicals) /
                      Peptides (NLM Chemicals)},
      cin          = {AG Öckl / Clinical Study Center (Ulm)},
      ddc          = {610},
      cid          = {I:(DE-2719)5000073 / I:(DE-2719)5000077},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40681694},
      doi          = {10.1038/s44321-025-00272-w},
      url          = {https://pub.dzne.de/record/280293},
}