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@ARTICLE{Sammons:280426,
      author       = {Sammons, Rosanna P and Masserini, Stefano and Moreno
                      Velasquez, Laura and Metodieva, Verjinia D and Cano, Gaspar
                      and Sannio, Andrea and Orlando, Marta and Maier, Nikolaus
                      and Kempter, Richard and Schmitz, Dietmar},
      title        = {{S}ub-type specific connectivity between {CA}3 pyramidal
                      neurons may underlie their sequential activation during
                      sharp waves.},
      journal      = {eLife},
      volume       = {13},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DZNE-2025-00953},
      pages        = {RP98653},
      year         = {2025},
      abstract     = {The CA3 region of the hippocampus is the major site of
                      sharp wave initiation, and a brain region crucially involved
                      in learning and memory. Highly recurrent connectivity within
                      its excitatory network is thought to underlie processes
                      involved in memory formation. Recent work has indicated that
                      distinct subpopulations of pyramidal neurons within this
                      region may contribute differently to network activity,
                      including sharp waves, in CA3. Exactly how these
                      contributions may arise is not yet known. Here, we
                      disentangle the local connectivity between two distinct CA3
                      cell types in mice: thorny and athorny pyramidal cells. We
                      find an asymmetry in the connectivity between these two
                      populations, with athorny cells receiving strong input from
                      both athorny and thorny cells. Conversely, the thorny cell
                      population receives very little input from the athorny
                      population. Computational modeling suggests that this
                      connectivity scheme may determine the sequential activation
                      of these cell types during large network events such as
                      sharp waves.},
      keywords     = {CA3 (Other) / connectivity (Other) / hippocampus (Other) /
                      learning (Other) / memory (Other) / mouse (Other) /
                      neuroscience (Other) / pyramidal cells (Other) / sharp waves
                      (Other)},
      cin          = {AG Schmitz},
      ddc          = {600},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40814825},
      pmc          = {pmc:PMC12356639},
      doi          = {10.7554/eLife.98653},
      url          = {https://pub.dzne.de/record/280426},
}