%0 Journal Article
%A Sharew, Nigussie T
%A Clark, Scott R
%A Papiol, Sergi
%A Heilbronner, Urs
%A Degenhardt, Franziska
%A Fullerton, Janice M
%A Hou, Liping
%A Shekhtman, Tatyana
%A Adli, Mazda
%A Akula, Nirmala
%A Akiyama, Kazufumi
%A Ardau, Raffaella
%A Arias, Bárbara
%A Hasler, Roland
%A Richard-Lepouriel, Hélène
%A Perroud, Nader
%A Backlund, Lena
%A Bhattacharjee, Abesh Kumar
%A Bellivier, Frank
%A Benabarre, Antonio
%A Bengesser, Susanne
%A Biernacka, Joanna M
%A Birner, Armin
%A Marie-Claire, Cynthia
%A Cervantes, Pablo
%A Chen, Hsi-Chung
%A Chillotti, Caterina
%A Cichon, Sven
%A Cruceanu, Cristiana
%A Czerski, Piotr M
%A Dalkner, Nina
%A Del Zompo, Maria
%A DePaulo, J Raymond
%A Étain, Bruno
%A Jamain, Stephane
%A Falkai, Peter
%A Forstner, Andreas J
%A Frisen, Louise
%A Frye, Mark A
%A Gard, Sébastien
%A Garnham, Julie S
%A Goes, Fernando S
%A Grigoroiu-Serbanescu, Maria
%A Fallgatter, Andreas
%A Stegmaier, Sophia
%A Ethofer, Thomas
%A Biere, Silvia
%A Petrova, Kristiyana
%A Schuster, Ceylan
%A Adorjan, Kristina
%A Budde, Monika
%A Heilbronner, Maria
%A Kalman, Janos L
%A Kohshour, Mojtaba Oraki
%A Reich-Erkelenz, Daniela
%A Schaupp, Sabrina K
%A Schulte, Eva C
%A Senner, Fanny
%A Vogl, Thomas
%A Anghelescu, Ion-George
%A Arolt, Volker
%A Dannlowski, Udo
%A Dietrich, Detlef E
%A Figge, Christian
%A Jäger, Markus
%A Lang, Fabian U
%A Juckel, Georg
%A Konrad, Carsten
%A Reimer, Jens
%A Schmauß, Max
%A Schmitt, Andrea
%A Spitzer, Carsten
%A von Hagen, Martin
%A Wiltfang, Jens
%A Zimmermann, Jörg
%A Fischer, Andre
%A Bermpohl, Felix
%A Ritter, Philipp
%A Matura, Silke
%A Gryaznova, Anna
%A Falkenberg, Irina
%A Yildiz, Cüneyt
%A Kircher, Tilo
%A Schmidt, Julia
%A Koch, Marius
%A Gade, Kathrin
%A Trost, Sarah
%A Andlauer, Till F M
%A Haussleiter, Ida S
%A Lambert, Martin
%A Rohenkohl, Anja C
%A Kraft, Vivien
%A Grof, Paul
%A Hashimoto, Ryota
%A Hauser, Joanna
%A Herms, Stefan
%A Hoffmann, Per
%A Jiménez, Esther
%A Kahn, Jean-Pierre
%A Kassem, Layla
%A Kuo, Po-Hsiu
%A Kato, Tadafumi
%A Kelsoe, John
%A Kittel-Schneider, Sarah
%A Ferensztajn-Rochowiak, Ewa
%A König, Barbara
%A Kusumi, Ichiro
%A Laje, Gonzalo
%A Landén, Mikael
%A Lavebratt, Catharina
%A Leboyer, Marion
%A Leckband, Susan G
%A Tortorella, Alfonso
%A Manchia, Mirko
%A Martinsson, Lina
%A McCarthy, Michael J
%A McElroy, Susan
%A Colom, Francesc
%A Millischer, Vincent
%A Mitjans, Marina
%A Mondimore, Francis M
%A Monteleone, Palmiero
%A Nievergelt, Caroline M
%A Nöthen, Markus M
%A Novák, Tomas
%A O'Donovan, Claire
%A Ozaki, Norio
%A Pfennig, Andrea
%A Pisanu, Claudia
%A Potash, James B
%A Reif, Andreas
%A Reininghaus, Eva
%A Rouleau, Guy A
%A Rybakowski, Janusz K
%A Schalling, Martin
%A Schofield, Peter R
%A Schweizer, Barbara W
%A Severino, Giovanni
%A Shilling, Paul D
%A Shimoda, Katzutaka
%A Simhandl, Christian
%A Slaney, Claire M
%A Squassina, Alessio
%A Stamm, Thomas
%A Stopkova, Pavla
%A Maj, Mario
%A Turecki, Gustavo
%A Vieta, Eduard
%A Veeh, Julia
%A Viswanath, Biju
%A Witt, Stephanie H
%A Wright, Adam
%A Zandi, Peter P
%A Mitchell, Philip B
%A Bauer, Michael
%A Alda, Martin
%A Rietschel, Marcella
%A McMahon, Francis J
%A Schulze, Thomas G
%A Baune, Bernhard T
%A Schubert, Klaus Oliver
%A Amare, Azmeraw T
%T Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.
%J Biological psychiatry: global open science
%V 5
%N 5
%@ 2667-1743
%C Amsterdam
%I Elsevier
%M DZNE-2025-00963
%P 100558
%D 2025
%X Polygenic scores (PGSs) hold the potential to identify patients who respond favorably to specific psychiatric treatments. However, their biological interpretation remains unclear. In this study, we developed pathway-specific PGSs (PSPGSs) for lithium response and assessed their association with clinical lithium response in patients with bipolar disorder.Using sets of genes involved in pathways affected by lithium, we developed 9 PSPGSs and evaluated their associations with lithium response in the International Consortium on Lithium Genetics (ConLi+Gen) (N = 2367), with validation in combined PsyCourse (Pathomechanisms and Signatures in the Longitudinal Course of Psychosis) (N = 105) and BipoLife (N = 102) cohorts. The association between each PSPGS and lithium response-defined both as a continuous ALDA score and a categorical outcome (good vs. poor responses)-was evaluated using regression models, with adjustment for confounders. The cutoff for a significant association was p < .05 after multiple testing correction.The PGSs for acetylcholine, GABA (gamma-aminobutyric acid), and mitochondria were associated with response to lithium in both categorical and continuous outcomes. However, the PGSs for calcium channel, circadian rhythm, and GSK (glycogen synthase kinase) were associated only with the continuous outcome. Each score explained 0.29
%K Bipolar disorder (Other)
%K Lithium (Other)
%K Pharmacogenomics (Other)
%K Polygenic score (Other)
%K Psychiatry (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40821394
%2 pmc:PMC12357302
%R 10.1016/j.bpsgos.2025.100558
%U https://pub.dzne.de/record/280742