TY  - JOUR
AU  - Alberti, Simon
AU  - Arosio, Paolo
AU  - Best, Robert B
AU  - Boeynaems, Steven
AU  - Cai, Danfeng
AU  - Collepardo-Guevara, Rosana
AU  - Dignon, Gregory L
AU  - Dimova, Rumiana
AU  - Elbaum-Garfinkle, Shana
AU  - Fawzi, Nicolas L
AU  - Fuxreiter, Monika
AU  - Gladfelter, Amy S
AU  - Honigmann, Alf
AU  - Jain, Ankur
AU  - Joseph, Jerelle A
AU  - Knowles, Tuomas P J
AU  - Lasker, Keren
AU  - Lemke, Edward A
AU  - Lindorff-Larsen, Kresten
AU  - Lipowsky, Reinhard
AU  - Mittal, Jeetain
AU  - Mukhopadhyay, Samrat
AU  - Myong, Sua
AU  - Pappu, Rohit V
AU  - Rippe, Karsten
AU  - Shelkovnikova, Tatyana A
AU  - Vecchiarelli, Anthony G
AU  - Wegmann, Susanne
AU  - Zhang, Huaiying
AU  - Zhang, Mingjie
AU  - Zubieta, Chloe
AU  - Zweckstetter, Markus
AU  - Dormann, Dorothee
AU  - Mittag, Tanja
TI  - Current practices in the study of biomolecular condensates: a community comment.
JO  - Nature Communications
VL  - 16
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-00964
SP  - 7730
PY  - 2025
AB  -  The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes, fundamentally changing the study of biology. The term biomolecular condensate refers to non-stoichiometric assemblies that are composed of multiple types of macromolecules in cells, occur through phase transitions, and can be investigated by using concepts from soft matter physics. As such, they are intimately related to aqueous two-phase systems and water-in-water emulsions. Condensates possess tunable emergent properties such as interfaces, interfacial tension, viscoelasticity, network structure, dielectric permittivity, and sometimes interphase pH gradients and electric potentials–. They can form spontaneously in response to specific cellular conditions or to active processes, and cells appear to have mechanisms to control their size and location–. Importantly, in contrast to membrane-enclosed organelles such as mitochondria or peroxisomes, condensates do not require the presence of a surrounding membrane.
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC12365244
C6  - pmid:40830340
DO  - DOI:10.1038/s41467-025-62055-8
UR  - https://pub.dzne.de/record/280743
ER  -