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@ARTICLE{Alberti:280743,
author = {Alberti, Simon and Arosio, Paolo and Best, Robert B and
Boeynaems, Steven and Cai, Danfeng and Collepardo-Guevara,
Rosana and Dignon, Gregory L and Dimova, Rumiana and
Elbaum-Garfinkle, Shana and Fawzi, Nicolas L and Fuxreiter,
Monika and Gladfelter, Amy S and Honigmann, Alf and Jain,
Ankur and Joseph, Jerelle A and Knowles, Tuomas P J and
Lasker, Keren and Lemke, Edward A and Lindorff-Larsen,
Kresten and Lipowsky, Reinhard and Mittal, Jeetain and
Mukhopadhyay, Samrat and Myong, Sua and Pappu, Rohit V and
Rippe, Karsten and Shelkovnikova, Tatyana A and
Vecchiarelli, Anthony G and Wegmann, Susanne and Zhang,
Huaiying and Zhang, Mingjie and Zubieta, Chloe and
Zweckstetter, Markus and Dormann, Dorothee and Mittag,
Tanja},
title = {{C}urrent practices in the study of biomolecular
condensates: a community comment.},
journal = {Nature Communications},
volume = {16},
number = {1},
issn = {2041-1723},
address = {[London]},
publisher = {Springer Nature},
reportid = {DZNE-2025-00964},
pages = {7730},
year = {2025},
abstract = {The realization that the cell is abundantly
compartmentalized into biomolecular condensates has opened
new opportunities for understanding the physics and
chemistry underlying many cellular processes, fundamentally
changing the study of biology. The term biomolecular
condensate refers to non-stoichiometric assemblies that are
composed of multiple types of macromolecules in cells, occur
through phase transitions, and can be investigated by using
concepts from soft matter physics. As such, they are
intimately related to aqueous two-phase systems and
water-in-water emulsions. Condensates possess tunable
emergent properties such as interfaces, interfacial tension,
viscoelasticity, network structure, dielectric permittivity,
and sometimes interphase pH gradients and electric
potentials–. They can form spontaneously in response to
specific cellular conditions or to active processes, and
cells appear to have mechanisms to control their size and
location–. Importantly, in contrast to membrane-enclosed
organelles such as mitochondria or peroxisomes, condensates
do not require the presence of a surrounding membrane.},
subtyp = {Editorial},
cin = {AG Wegmann / AG Zweckstetter},
ddc = {500},
cid = {I:(DE-2719)1810006 / I:(DE-2719)1410001},
pnm = {352 - Disease Mechanisms (POF4-352)},
pid = {G:(DE-HGF)POF4-352},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC12365244},
pubmed = {pmid:40830340},
doi = {10.1038/s41467-025-62055-8},
url = {https://pub.dzne.de/record/280743},
}