%0 Journal Article
%A Van der Auwera, Sandra
%A Ameling, Sabine
%A Wiechert, Anja
%A Friedrich, Nele
%A Nauck, Matthias
%A Völzke, Henry
%A Bröker, Barbara M
%A Grabe, Hans J
%A Völker, Uwe
%T Circulating miRNAs and inflammatory markers - Associations between miRNAs and cytokine levels point to miRNA-mediated sCD40L release from platelets.
%J Cytokine
%V 194
%@ 1043-4666
%C Oxford ˜[u.a.]œ
%I Elsevier
%M DZNE-2025-00968
%P 157012
%D 2025
%X MicroRNAs (miRNAs) are gaining increasing attention, particularly because of their involvement in immune-related signaling pathways. We investigated the association between 179 plasma-circulating miRNAs (Plasma Focus microRNA PCR Panel) and 47 cytokines ('MILLIPLEX® panel) in 692 participants of the population-based SHIP-TREND cohort (age range 21-79) and two additional cohorts to present a comprehensive map of miRNA-cytokine relations. Multivariate linear regression models identified Bonferroni-corrected significant associations between miRNAs and cytokines for EGF (pro-epidermal growth factor), PDGF-AA, PDGF-AB/BB (platelet-derived growth factor subunit A and B), VEGF-A (vascular endothelia growth factor A), and sCD40L (soluble CD40 ligand) with sCD40L showing the most robust pattern. These models were adjusted for age, sex, platelet count, BMI, smoking, and technical parameters. In the follow-up sample (N = 191, 7 years after initial sampling), we confirmed that the observed associations were stable over time and replicated our findings in an independent clinical cohort (N = 74). Furthermore, the causal mediation results provide evidence for the involvement of platelet activity in the regulation of sCD40L mediated by five miRNAs in the range of 25 
%K Humans
%K CD40 Ligand: blood
%K CD40 Ligand: metabolism
%K Male
%K Female
%K Middle Aged
%K Blood Platelets: metabolism
%K Adult
%K Cytokines: blood
%K MicroRNAs: blood
%K MicroRNAs: genetics
%K Aged
%K Biomarkers: blood
%K Circulating MicroRNA: blood
%K Circulating MicroRNA: genetics
%K Inflammation: blood
%K Young Adult
%K Cohort Studies
%K Circulating biomarkers (Other)
%K Platelet activation (Other)
%K SHIP study (Other)
%K miRNA mediated sCD40L release (Other)
%K miRNA-cytokine association (Other)
%K CD40 Ligand (NLM Chemicals)
%K Cytokines (NLM Chemicals)
%K MicroRNAs (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Circulating MicroRNA (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40803257
%R 10.1016/j.cyto.2025.157012
%U https://pub.dzne.de/record/280784