%0 Journal Article
%A Bartels, Claudia
%A Tzu-Yueh Chen, Joy
%A Belz, Michael
%A Yakupov, Renat
%A Düzel, Emrah
%A Glanz, Wenzel
%A Lüsebrink, Falk
%A Dechent, Peter
%A Kleineidam, Luca
%A Stark, Melina
%A Spottke, Annika
%A Coenjaerts, Marie
%A Fließbach, Klaus
%A Schneider, Anja
%A Rostamzadeh, Ayda
%A Jessen, Frank
%A Schott, Björn
%A Wiltfang, Jens
%A Frommann, Ingo
%A Wagner, Michael
%A Goya-Maldonado, Roberto
%T Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.
%J Alzheimer's research & therapy
%V 17
%N 1
%@ 1758-9193
%C London
%I BioMed Central
%M DZNE-2025-00969
%P 195
%D 2025
%X Long-term retrieval (LTR) and accelerated long-term forgetting (ALF) paradigms might help differentiating individuals at increased dementia risk from healthy controls (HC).We investigated the utility of a LTR paradigm in discriminating subjective cognitive decline (SCD) from HC and its relationship to the CA1 body volume, a hippocampal structure pivotal to the memory circuitry.LTR was assessed via recall rates of the ADAS-cog word list and the FCSRT-IR free recall in 59 DELCODE study participants, including individuals with SCD and mild cognitive impairment (MCI), as well as HC, all of them DELCODE study participants. LTR performance was compared between groups and its discriminability between SCD and HC was assessed using ROC curve analysis. 32 SCD and HC participants had FreeSurfer-segmented MRI data, and hippocampal subfield volumes were correlated with LTR rates.Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95
%K Humans
%K Male
%K Female
%K Aged
%K Magnetic Resonance Imaging
%K CA1 Region, Hippocampal: diagnostic imaging
%K CA1 Region, Hippocampal: pathology
%K Cognitive Dysfunction: diagnostic imaging
%K Cognitive Dysfunction: pathology
%K Cognitive Dysfunction: psychology
%K Dementia: diagnostic imaging
%K Dementia: psychology
%K Dementia: pathology
%K Mental Recall: physiology
%K Aged, 80 and over
%K Neuropsychological Tests
%K Organ Size
%K Alzheimer’s disease (Other)
%K Consolidation (Other)
%K Dementia (Other)
%K Hippocampus (Other)
%K Long-term retrieval (Other)
%K Memory (Other)
%K Mild cognitive impairment (Other)
%K Subjective cognitive decline (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40847320
%2 pmc:PMC12372344
%R 10.1186/s13195-025-01833-4
%U https://pub.dzne.de/record/280785