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000280785 1001_ $$aBartels, Claudia$$b0
000280785 245__ $$aLong-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.
000280785 260__ $$aLondon$$bBioMed Central$$c2025
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000280785 520__ $$aLong-term retrieval (LTR) and accelerated long-term forgetting (ALF) paradigms might help differentiating individuals at increased dementia risk from healthy controls (HC).We investigated the utility of a LTR paradigm in discriminating subjective cognitive decline (SCD) from HC and its relationship to the CA1 body volume, a hippocampal structure pivotal to the memory circuitry.LTR was assessed via recall rates of the ADAS-cog word list and the FCSRT-IR free recall in 59 DELCODE study participants, including individuals with SCD and mild cognitive impairment (MCI), as well as HC, all of them DELCODE study participants. LTR performance was compared between groups and its discriminability between SCD and HC was assessed using ROC curve analysis. 32 SCD and HC participants had FreeSurfer-segmented MRI data, and hippocampal subfield volumes were correlated with LTR rates.Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95% CI 0.537-0.865). Moderate associations of the FCSRT-IR LTR rate with CA1 bodies in both hemispheres (left CA1 body r = 0.419, p = 0.017; right: r = 0.412, p = 0.019), in addition to the left C3 body were observed (r = 0.525, p = 0.002).LTR may constitute a potential indicator of memory circuitry integrity in older adults, which is also mirrored by its association with CA1 volume. Thus, assessment of LTR and associated neural circuits may help to better identify individuals at risk for future cognitive decline today indistinguishable from HC, ultimately paving the way for early intervention.
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000280785 650_7 $$2Other$$aAlzheimer’s disease
000280785 650_7 $$2Other$$aConsolidation
000280785 650_7 $$2Other$$aDementia
000280785 650_7 $$2Other$$aHippocampus
000280785 650_7 $$2Other$$aLong-term retrieval
000280785 650_7 $$2Other$$aMemory
000280785 650_7 $$2Other$$aMild cognitive impairment
000280785 650_7 $$2Other$$aSubjective cognitive decline
000280785 650_2 $$2MeSH$$aHumans
000280785 650_2 $$2MeSH$$aMale
000280785 650_2 $$2MeSH$$aFemale
000280785 650_2 $$2MeSH$$aAged
000280785 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000280785 650_2 $$2MeSH$$aCA1 Region, Hippocampal: diagnostic imaging
000280785 650_2 $$2MeSH$$aCA1 Region, Hippocampal: pathology
000280785 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000280785 650_2 $$2MeSH$$aCognitive Dysfunction: pathology
000280785 650_2 $$2MeSH$$aCognitive Dysfunction: psychology
000280785 650_2 $$2MeSH$$aDementia: diagnostic imaging
000280785 650_2 $$2MeSH$$aDementia: psychology
000280785 650_2 $$2MeSH$$aDementia: pathology
000280785 650_2 $$2MeSH$$aMental Recall: physiology
000280785 650_2 $$2MeSH$$aAged, 80 and over
000280785 650_2 $$2MeSH$$aNeuropsychological Tests
000280785 650_2 $$2MeSH$$aOrgan Size
000280785 7001_ $$aTzu-Yueh Chen, Joy$$b1
000280785 7001_ $$aBelz, Michael$$b2
000280785 7001_ $$0P:(DE-2719)2812398$$aYakupov, Renat$$b3$$udzne
000280785 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b4$$udzne
000280785 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b5$$udzne
000280785 7001_ $$0P:(DE-2719)9002520$$aLüsebrink, Falk$$b6$$udzne
000280785 7001_ $$aDechent, Peter$$b7
000280785 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b8$$udzne
000280785 7001_ $$0P:(DE-2719)9001773$$aStark, Melina$$b9$$udzne
000280785 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b10$$udzne
000280785 7001_ $$0P:(DE-HGF)0$$aCoenjaerts, Marie$$b11
000280785 7001_ $$0P:(DE-2719)2811326$$aFließbach, Klaus$$b12$$udzne
000280785 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b13$$udzne
000280785 7001_ $$aRostamzadeh, Ayda$$b14
000280785 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b15$$udzne
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000280785 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b17$$udzne
000280785 7001_ $$0P:(DE-2719)2810481$$aFrommann, Ingo$$b18$$udzne
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000280785 7001_ $$aGoya-Maldonado, Roberto$$b20
000280785 773__ $$0PERI:(DE-600)2506521-X$$a10.1186/s13195-025-01833-4$$gVol. 17, no. 1, p. 195$$n1$$p195$$tAlzheimer's research & therapy$$v17$$x1758-9193$$y2025
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