TY  - JOUR
AU  - Bartels, Claudia
AU  - Tzu-Yueh Chen, Joy
AU  - Belz, Michael
AU  - Yakupov, Renat
AU  - Düzel, Emrah
AU  - Glanz, Wenzel
AU  - Lüsebrink, Falk
AU  - Dechent, Peter
AU  - Kleineidam, Luca
AU  - Stark, Melina
AU  - Spottke, Annika
AU  - Coenjaerts, Marie
AU  - Fließbach, Klaus
AU  - Schneider, Anja
AU  - Rostamzadeh, Ayda
AU  - Jessen, Frank
AU  - Schott, Björn
AU  - Wiltfang, Jens
AU  - Frommann, Ingo
AU  - Wagner, Michael
AU  - Goya-Maldonado, Roberto
TI  - Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.
JO  - Alzheimer's research & therapy
VL  - 17
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DZNE-2025-00969
SP  - 195
PY  - 2025
AB  - Long-term retrieval (LTR) and accelerated long-term forgetting (ALF) paradigms might help differentiating individuals at increased dementia risk from healthy controls (HC).We investigated the utility of a LTR paradigm in discriminating subjective cognitive decline (SCD) from HC and its relationship to the CA1 body volume, a hippocampal structure pivotal to the memory circuitry.LTR was assessed via recall rates of the ADAS-cog word list and the FCSRT-IR free recall in 59 DELCODE study participants, including individuals with SCD and mild cognitive impairment (MCI), as well as HC, all of them DELCODE study participants. LTR performance was compared between groups and its discriminability between SCD and HC was assessed using ROC curve analysis. 32 SCD and HC participants had FreeSurfer-segmented MRI data, and hippocampal subfield volumes were correlated with LTR rates.Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95
KW  - Humans
KW  - Male
KW  - Female
KW  - Aged
KW  - Magnetic Resonance Imaging
KW  - CA1 Region, Hippocampal: diagnostic imaging
KW  - CA1 Region, Hippocampal: pathology
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: pathology
KW  - Cognitive Dysfunction: psychology
KW  - Dementia: diagnostic imaging
KW  - Dementia: psychology
KW  - Dementia: pathology
KW  - Mental Recall: physiology
KW  - Aged, 80 and over
KW  - Neuropsychological Tests
KW  - Organ Size
KW  - Alzheimer’s disease (Other)
KW  - Consolidation (Other)
KW  - Dementia (Other)
KW  - Hippocampus (Other)
KW  - Long-term retrieval (Other)
KW  - Memory (Other)
KW  - Mild cognitive impairment (Other)
KW  - Subjective cognitive decline (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40847320
C2  - pmc:PMC12372344
DO  - DOI:10.1186/s13195-025-01833-4
UR  - https://pub.dzne.de/record/280785
ER  -