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@ARTICLE{Bartels:280785,
      author       = {Bartels, Claudia and Tzu-Yueh Chen, Joy and Belz, Michael
                      and Yakupov, Renat and Düzel, Emrah and Glanz, Wenzel and
                      Lüsebrink, Falk and Dechent, Peter and Kleineidam, Luca and
                      Stark, Melina and Spottke, Annika and Coenjaerts, Marie and
                      Fließbach, Klaus and Schneider, Anja and Rostamzadeh, Ayda
                      and Jessen, Frank and Schott, Björn and Wiltfang, Jens and
                      Frommann, Ingo and Wagner, Michael and Goya-Maldonado,
                      Roberto},
      title        = {{L}ong-term retrieval performance is associated with {CA}1
                      hippocampal volume in older adults and individuals at risk
                      for dementia.},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {17},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2025-00969},
      pages        = {195},
      year         = {2025},
      abstract     = {Long-term retrieval (LTR) and accelerated long-term
                      forgetting (ALF) paradigms might help differentiating
                      individuals at increased dementia risk from healthy controls
                      (HC).We investigated the utility of a LTR paradigm in
                      discriminating subjective cognitive decline (SCD) from HC
                      and its relationship to the CA1 body volume, a hippocampal
                      structure pivotal to the memory circuitry.LTR was assessed
                      via recall rates of the ADAS-cog word list and the FCSRT-IR
                      free recall in 59 DELCODE study participants, including
                      individuals with SCD and mild cognitive impairment (MCI), as
                      well as HC, all of them DELCODE study participants. LTR
                      performance was compared between groups and its
                      discriminability between SCD and HC was assessed using ROC
                      curve analysis. 32 SCD and HC participants had
                      FreeSurfer-segmented MRI data, and hippocampal subfield
                      volumes were correlated with LTR rates.Only FCSRT-IR LTR
                      rates sufficiently differentiated SCD from HC (AUC of 0.701;
                      $95\%$ CI 0.537-0.865). Moderate associations of the
                      FCSRT-IR LTR rate with CA1 bodies in both hemispheres (left
                      CA1 body r = 0.419, p = 0.017; right: r = 0.412, p = 0.019),
                      in addition to the left C3 body were observed (r = 0.525, p
                      = 0.002).LTR may constitute a potential indicator of memory
                      circuitry integrity in older adults, which is also mirrored
                      by its association with CA1 volume. Thus, assessment of LTR
                      and associated neural circuits may help to better identify
                      individuals at risk for future cognitive decline today
                      indistinguishable from HC, ultimately paving the way for
                      early intervention.},
      keywords     = {Humans / Male / Female / Aged / Magnetic Resonance Imaging
                      / CA1 Region, Hippocampal: diagnostic imaging / CA1 Region,
                      Hippocampal: pathology / Cognitive Dysfunction: diagnostic
                      imaging / Cognitive Dysfunction: pathology / Cognitive
                      Dysfunction: psychology / Dementia: diagnostic imaging /
                      Dementia: psychology / Dementia: pathology / Mental Recall:
                      physiology / Aged, 80 and over / Neuropsychological Tests /
                      Organ Size / Alzheimer’s disease (Other) / Consolidation
                      (Other) / Dementia (Other) / Hippocampus (Other) / Long-term
                      retrieval (Other) / Memory (Other) / Mild cognitive
                      impairment (Other) / Subjective cognitive decline (Other)},
      cin          = {AG Düzel / AG Spottke / AG Wagner / Patient Studies (Bonn)
                      / AG Schneider / AG Jessen / AG Fischer / AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1011103 /
                      I:(DE-2719)1011201 / I:(DE-2719)1011101 / I:(DE-2719)1011305
                      / I:(DE-2719)1011102 / I:(DE-2719)1410002 /
                      I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40847320},
      pmc          = {pmc:PMC12372344},
      doi          = {10.1186/s13195-025-01833-4},
      url          = {https://pub.dzne.de/record/280785},
}