Home > Publications Database > Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia. > print

001     280785
005     20250907001858.0
024 7 _ |a 10.1186/s13195-025-01833-4
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037 _ _ |a DZNE-2025-00969
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Bartels, Claudia
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245 _ _ |a Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.
260 _ _ |a London
|c 2025
|b BioMed Central
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520 _ _ |a Long-term retrieval (LTR) and accelerated long-term forgetting (ALF) paradigms might help differentiating individuals at increased dementia risk from healthy controls (HC).We investigated the utility of a LTR paradigm in discriminating subjective cognitive decline (SCD) from HC and its relationship to the CA1 body volume, a hippocampal structure pivotal to the memory circuitry.LTR was assessed via recall rates of the ADAS-cog word list and the FCSRT-IR free recall in 59 DELCODE study participants, including individuals with SCD and mild cognitive impairment (MCI), as well as HC, all of them DELCODE study participants. LTR performance was compared between groups and its discriminability between SCD and HC was assessed using ROC curve analysis. 32 SCD and HC participants had FreeSurfer-segmented MRI data, and hippocampal subfield volumes were correlated with LTR rates.Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95% CI 0.537-0.865). Moderate associations of the FCSRT-IR LTR rate with CA1 bodies in both hemispheres (left CA1 body r = 0.419, p = 0.017; right: r = 0.412, p = 0.019), in addition to the left C3 body were observed (r = 0.525, p = 0.002).LTR may constitute a potential indicator of memory circuitry integrity in older adults, which is also mirrored by its association with CA1 volume. Thus, assessment of LTR and associated neural circuits may help to better identify individuals at risk for future cognitive decline today indistinguishable from HC, ultimately paving the way for early intervention.
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650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Consolidation
|2 Other
650 _ 7 |a Dementia
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650 _ 7 |a Hippocampus
|2 Other
650 _ 7 |a Long-term retrieval
|2 Other
650 _ 7 |a Memory
|2 Other
650 _ 7 |a Mild cognitive impairment
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650 _ 7 |a Subjective cognitive decline
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a CA1 Region, Hippocampal: diagnostic imaging
|2 MeSH
650 _ 2 |a CA1 Region, Hippocampal: pathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: diagnostic imaging
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: psychology
|2 MeSH
650 _ 2 |a Dementia: diagnostic imaging
|2 MeSH
650 _ 2 |a Dementia: psychology
|2 MeSH
650 _ 2 |a Dementia: pathology
|2 MeSH
650 _ 2 |a Mental Recall: physiology
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Neuropsychological Tests
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650 _ 2 |a Organ Size
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700 1 _ |a Tzu-Yueh Chen, Joy
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700 1 _ |a Belz, Michael
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700 1 _ |a Yakupov, Renat
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700 1 _ |a Düzel, Emrah
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700 1 _ |a Glanz, Wenzel
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700 1 _ |a Lüsebrink, Falk
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700 1 _ |a Dechent, Peter
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700 1 _ |a Kleineidam, Luca
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700 1 _ |a Fließbach, Klaus
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700 1 _ |a Schneider, Anja
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700 1 _ |a Schott, Björn
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700 1 _ |a Frommann, Ingo
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700 1 _ |a Wagner, Michael
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700 1 _ |a Goya-Maldonado, Roberto
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773 _ _ |a 10.1186/s13195-025-01833-4
|g Vol. 17, no. 1, p. 195
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|t Alzheimer's research & therapy
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