%0 Journal Article
%A Steinacker, Petra
%A Werner, Leonie
%A Tarabuko, Alexander
%A Al-Ali, Ilyas
%A Mechawar, Naguib
%A Pryce, Christopher R
%A Cattane, Nadia
%A Poggi, Giulia
%A Al Shweiki, Mhd Rami
%A Graf, Heiko
%A Großkopf, Henning
%A Halbgebauer, Steffen
%A Oeckl, Patrick
%A Barba, Lorenzo
%A Meier, Laura
%A Abu-Rumeileh, Samir
%A Marston, Hugh
%A Bornemann, Klaus D
%A Hengerer, Bastian
%A Danzer, Karin M
%A Schönfeldt-Lecuona, Carlos
%A Otto, Markus
%T Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia.
%J BMJ mental health
%V 28
%N 1
%@ 1362-0347
%C London
%I BMJ Publ. Group
%M DZNE-2025-00974
%P e301752
%D 2025
%X Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD).To investigate the diagnostic utility of the soluble N-ethylmaleimide-sensitive-factor attachment receptor (SNARE) complex protein, synaptosomal-associated protein of 25 kDa (SNAP-25), for MDD.Overall, 208 participants with one of MDD, schizophrenia (SCZ) or bipolar disorder (BD), and healthy controls (HCs) were retrospectively enrolled. CSF levels of SNAP-25 were assessed relative to MDD characteristics and the diagnostic potential was analysed. In subgroups of patients, CSF levels of presynaptic neurexin 3 (NRXN3), postsynaptic neurogranin (NRGN) and Alzheimer's disease biomarkers were measured for comparison.SNAP-25 levels, but not the levels of the other synaptic markers, were significantly decreased in MDD compared with HCs, allowing for discrimination with 68
%K Humans
%K Synaptosomal-Associated Protein 25: cerebrospinal fluid
%K Depressive Disorder, Major: cerebrospinal fluid
%K Depressive Disorder, Major: diagnosis
%K Schizophrenia: cerebrospinal fluid
%K Schizophrenia: diagnosis
%K Male
%K Female
%K Adult
%K Middle Aged
%K Biomarkers: cerebrospinal fluid
%K Retrospective Studies
%K Neurogranin: cerebrospinal fluid
%K Bipolar Disorder: cerebrospinal fluid
%K Sensitivity and Specificity
%K Cross-Sectional Studies (Other)
%K Depression (Other)
%K Synaptosomal-Associated Protein 25 (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K SNAP25 protein, human (NLM Chemicals)
%K Neurogranin (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40840974
%2 pmc:PMC12374683
%R 10.1136/bmjment-2025-301752
%U https://pub.dzne.de/record/280790