TY  - JOUR
AU  - Steinacker, Petra
AU  - Werner, Leonie
AU  - Tarabuko, Alexander
AU  - Al-Ali, Ilyas
AU  - Mechawar, Naguib
AU  - Pryce, Christopher R
AU  - Cattane, Nadia
AU  - Poggi, Giulia
AU  - Al Shweiki, Mhd Rami
AU  - Graf, Heiko
AU  - Großkopf, Henning
AU  - Halbgebauer, Steffen
AU  - Oeckl, Patrick
AU  - Barba, Lorenzo
AU  - Meier, Laura
AU  - Abu-Rumeileh, Samir
AU  - Marston, Hugh
AU  - Bornemann, Klaus D
AU  - Hengerer, Bastian
AU  - Danzer, Karin M
AU  - Schönfeldt-Lecuona, Carlos
AU  - Otto, Markus
TI  - Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia.
JO  - BMJ mental health
VL  - 28
IS  - 1
SN  - 1362-0347
CY  - London
PB  - BMJ Publ. Group
M1  - DZNE-2025-00974
SP  - e301752
PY  - 2025
AB  - Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD).To investigate the diagnostic utility of the soluble N-ethylmaleimide-sensitive-factor attachment receptor (SNARE) complex protein, synaptosomal-associated protein of 25 kDa (SNAP-25), for MDD.Overall, 208 participants with one of MDD, schizophrenia (SCZ) or bipolar disorder (BD), and healthy controls (HCs) were retrospectively enrolled. CSF levels of SNAP-25 were assessed relative to MDD characteristics and the diagnostic potential was analysed. In subgroups of patients, CSF levels of presynaptic neurexin 3 (NRXN3), postsynaptic neurogranin (NRGN) and Alzheimer's disease biomarkers were measured for comparison.SNAP-25 levels, but not the levels of the other synaptic markers, were significantly decreased in MDD compared with HCs, allowing for discrimination with 68
KW  - Humans
KW  - Synaptosomal-Associated Protein 25: cerebrospinal fluid
KW  - Depressive Disorder, Major: cerebrospinal fluid
KW  - Depressive Disorder, Major: diagnosis
KW  - Schizophrenia: cerebrospinal fluid
KW  - Schizophrenia: diagnosis
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Aged
KW  - Biomarkers: cerebrospinal fluid
KW  - Retrospective Studies
KW  - Neurogranin: cerebrospinal fluid
KW  - Bipolar Disorder: cerebrospinal fluid
KW  - Sensitivity and Specificity
KW  - Cross-Sectional Studies (Other)
KW  - Depression (Other)
KW  - Synaptosomal-Associated Protein 25 (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - SNAP25 protein, human (NLM Chemicals)
KW  - Neurogranin (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40840974
C2  - pmc:PMC12374683
DO  - DOI:10.1136/bmjment-2025-301752
UR  - https://pub.dzne.de/record/280790
ER  -