TY  - JOUR
AU  - Buchert, Ralph
AU  - Huppertz, Hans-Jürgen
AU  - Wegner, Florian
AU  - Berding, Georg
AU  - Brendel, Matthias
AU  - Apostolova, Ivayla
AU  - Buhmann, Carsten
AU  - Poetter-Nerger, Monika
AU  - Dierks, Alexander
AU  - Katzdobler, Sabrina
AU  - Klietz, Martin
AU  - Levin, Johannes
AU  - Mahmoudi, Nima
AU  - Rinscheid, Andreas
AU  - Quattrone, Andrea
AU  - Rogozinski, Sophia
AU  - Rumpf, Jost-Julian
AU  - Schneider, Christine
AU  - Stöcklein, Sophia
AU  - Spetsieris, Phoebe G
AU  - Eidelberg, David
AU  - Sabri, Osama
AU  - Barthel, Henryk
AU  - Wattjes, Mike P
AU  - Höglinger, Günter
TI  - Added value of FDG-PET for detection of progressive supranuclear palsy.
JO  - Journal of neurology, neurosurgery, and psychiatry
VL  - 96
IS  - 3
SN  - 0022-3050
CY  - London
PB  - BMJ Publishing Group
M1  - DZNE-2025-00977
SP  - 287 - 295
PY  - 2025
AB  - Diagnostic criteria for progressive supranuclear palsy (PSP) include midbrain atrophy in MRI and hypometabolism in [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) as supportive features. Due to limited data regarding their relative and sequential value, there is no recommendation for an algorithm to combine both modalities to increase diagnostic accuracy. This study evaluated the added value of sequential imaging using state-of-the-art methods to analyse the images regarding PSP features.The retrospective study included 41 PSP patients, 21 with Richardson's syndrome (PSP-RS), 20 with variant PSP phenotypes (vPSP) and 46 sex- and age-matched healthy controls. A pretrained support vector machine (SVM) for the classification of atrophy profiles from automatic MRI volumetry was used to analyse T1w-MRI (output: MRI-SVM-PSP score). Covariance pattern analysis was applied to compute the expression of a predefined PSP-related pattern in FDG-PET (output: PET-PSPRP expression score).The area under the receiver operating characteristic curve for the detection of PSP did not differ between MRI-SVM-PSP and PET-PSPRP expression score (p≥0.63): about 0.90, 0.95 and 0.85 for detection of all PSP, PSP-RS and vPSP. The MRI-SVM-PSP score achieved about 13
KW  - Humans
KW  - Supranuclear Palsy, Progressive: diagnostic imaging
KW  - Supranuclear Palsy, Progressive: pathology
KW  - Female
KW  - Male
KW  - Positron-Emission Tomography: methods
KW  - Fluorodeoxyglucose F18
KW  - Aged
KW  - Magnetic Resonance Imaging
KW  - Retrospective Studies
KW  - Middle Aged
KW  - Support Vector Machine
KW  - Radiopharmaceuticals
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Atrophy
KW  - IMAGE ANALYSIS (Other)
KW  - MOVEMENT DISORDERS (Other)
KW  - MRI (Other)
KW  - PET (Other)
KW  - SUPRANUCLEAR PALSY (Other)
KW  - Fluorodeoxyglucose F18 (NLM Chemicals)
KW  - Radiopharmaceuticals (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39107038
C2  - pmc:PMC12015049
DO  - DOI:10.1136/jnnp-2024-333590
UR  - https://pub.dzne.de/record/280893
ER  -