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@ARTICLE{Buchert:280893,
      author       = {Buchert, Ralph and Huppertz, Hans-Jürgen and Wegner,
                      Florian and Berding, Georg and Brendel, Matthias and
                      Apostolova, Ivayla and Buhmann, Carsten and Poetter-Nerger,
                      Monika and Dierks, Alexander and Katzdobler, Sabrina and
                      Klietz, Martin and Levin, Johannes and Mahmoudi, Nima and
                      Rinscheid, Andreas and Quattrone, Andrea and Rogozinski,
                      Sophia and Rumpf, Jost-Julian and Schneider, Christine and
                      Stöcklein, Sophia and Spetsieris, Phoebe G and Eidelberg,
                      David and Sabri, Osama and Barthel, Henryk and Wattjes, Mike
                      P and Höglinger, Günter},
      collaboration = {Initiative, Alzheimer’s Disease Neuroimaging},
      title        = {{A}dded value of {FDG}-{PET} for detection of progressive
                      supranuclear palsy.},
      journal      = {Journal of neurology, neurosurgery, and psychiatry},
      volume       = {96},
      number       = {3},
      issn         = {0022-3050},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DZNE-2025-00977},
      pages        = {287 - 295},
      year         = {2025},
      abstract     = {Diagnostic criteria for progressive supranuclear palsy
                      (PSP) include midbrain atrophy in MRI and hypometabolism in
                      [18F]fluorodeoxyglucose (FDG)-positron emission tomography
                      (PET) as supportive features. Due to limited data regarding
                      their relative and sequential value, there is no
                      recommendation for an algorithm to combine both modalities
                      to increase diagnostic accuracy. This study evaluated the
                      added value of sequential imaging using state-of-the-art
                      methods to analyse the images regarding PSP features.The
                      retrospective study included 41 PSP patients, 21 with
                      Richardson's syndrome (PSP-RS), 20 with variant PSP
                      phenotypes (vPSP) and 46 sex- and age-matched healthy
                      controls. A pretrained support vector machine (SVM) for the
                      classification of atrophy profiles from automatic MRI
                      volumetry was used to analyse T1w-MRI (output: MRI-SVM-PSP
                      score). Covariance pattern analysis was applied to compute
                      the expression of a predefined PSP-related pattern in
                      FDG-PET (output: PET-PSPRP expression score).The area under
                      the receiver operating characteristic curve for the
                      detection of PSP did not differ between MRI-SVM-PSP and
                      PET-PSPRP expression score (p≥0.63): about 0.90, 0.95 and
                      0.85 for detection of all PSP, PSP-RS and vPSP. The
                      MRI-SVM-PSP score achieved about $13\%$ higher specificity
                      and about $15\%$ lower sensitivity than the PET-PSPRP
                      expression score. Decision tree models selected the
                      MRI-SVM-PSP score for the first branching and the PET-PSPRP
                      expression score for a second split of the subgroup with
                      normal MRI-SVM-PSP score, both in the whole sample and when
                      restricted to PSP-RS or vPSP.FDG-PET provides added value
                      for PSP-suspected patients with normal/inconclusive T1w-MRI,
                      regardless of PSP phenotype and the methods to analyse the
                      images for PSP-typical features.},
      keywords     = {Humans / Supranuclear Palsy, Progressive: diagnostic
                      imaging / Supranuclear Palsy, Progressive: pathology /
                      Female / Male / Positron-Emission Tomography: methods /
                      Fluorodeoxyglucose F18 / Aged / Magnetic Resonance Imaging /
                      Retrospective Studies / Middle Aged / Support Vector Machine
                      / Radiopharmaceuticals / Brain: diagnostic imaging / Brain:
                      pathology / Atrophy / IMAGE ANALYSIS (Other) / MOVEMENT
                      DISORDERS (Other) / MRI (Other) / PET (Other) / SUPRANUCLEAR
                      PALSY (Other) / Fluorodeoxyglucose F18 (NLM Chemicals) /
                      Radiopharmaceuticals (NLM Chemicals)},
      cin          = {AG Haass / Clinical Research (Munich) / AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007 / I:(DE-2719)1111015 /
                      I:(DE-2719)1111016},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39107038},
      pmc          = {pmc:PMC12015049},
      doi          = {10.1136/jnnp-2024-333590},
      url          = {https://pub.dzne.de/record/280893},
}